Klein W W, Stuhlinger W, Mahr G
Department of Int. Medicine, University Hospital, Graz, Austria.
Postgrad Med J. 1986;62 Suppl 1:108-10.
In a cross-over study in 26 patients with mild to moderate essential hypertension The antihypertensive efficacy of captopril 25 mg b.i.d., nifedipine 20 mg b.i.d. and the combination both drugs in non-responders to monotherapy was compared. Of 26 captropril-treated patients 7 were non-responders and needed the addition of nifedipine; of 26 nifedipine-treated patients 3 needed additional captopril. Seven out of 26 patients treated with captopril, 22/26 patients given nifedipine and 9/10 patients receiving the combination reported side effects. In 3 nifedipine patients, 1 captopril patient and 1 patient on both drugs, treatment had to be stopped because of side effects. Captopril and nifedipine in these doses are about equally effective both after acute and chronic administration. The response-rate is somewhat higher with nifedipine, but the side effects are significantly less with captopril. There was no significant additive effect with the combination of the two drugs.
在一项针对26例轻至中度原发性高血压患者的交叉研究中，比较了卡托普利25毫克每日两次、硝苯地平20毫克每日两次以及这两种药物联合使用对单一疗法无反应患者的降压效果。在26例接受卡托普利治疗的患者中，7例无反应，需要加用硝苯地平；在26例接受硝苯地平治疗的患者中，3例需要加用卡托普利。接受卡托普利治疗的26例患者中有7例、接受硝苯地平治疗的26例患者中有22例以及接受联合治疗的10例患者中有9例报告了副作用。在3例硝苯地平治疗患者、1例卡托普利治疗患者和1例同时使用两种药物的患者中，由于副作用不得不停止治疗。这些剂量的卡托普利和硝苯地平在急性和慢性给药后效果大致相同。硝苯地平的有效率略高，但卡托普利的副作用明显较少。两种药物联合使用没有显著的相加作用。
