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黄斑裂孔形成眼中的黄斑色素及其手术后的变化。

Macular Pigment in Eyes With Macular Hole Formation and Its Change After Surgery.

机构信息

Department of Ophthalmology, Seirei Hamamatsu General Hospital, Hamamatsu City, Shizuoka, Japan.

Department of Medical Spectroscopy, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.

出版信息

Transl Vis Sci Technol. 2020 Oct 26;9(11):28. doi: 10.1167/tvst.9.11.28. eCollection 2020 Oct.

DOI:10.1167/tvst.9.11.28
PMID:33173607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7594585/
Abstract

PURPOSE

To observe the macular pigment (MP) appearances in eyes with macular hole (MH) and clarify the origin of the appearances. The mechanisms underlying the development of MH are discussed based on the observation of MP.

METHODS

This observational case series included 33 eyes of 31 patients with MH who underwent vitrectomy. The MP optical density was measured using the two-wavelength fundus autofluorescence technique. The exact localization of MP was evaluated by comparing MP distribution images and optical coherent tomography B-scan images.

RESULTS

MP was missing at the MH. The area of the MP defect corresponded with the area of the defect of outer plexiform layer. MP was present in the retinal flap in stage 2 MH that included glia (Müller cells) and plexiform layers and in the operculum in stage 3 MH, which mainly comprised Müller cells. Cystic spaces in the outer plexiform layer surrounding stage 3 and 4 MHs showed a honeycomb appearance on MP images. MP reappeared to form an irregularly shaped pigment plane after surgical closure of MH. The MP optical volume did not change before and after surgery. Fellow eyes with a central dip in MP distribution subsequently developed MH.

CONCLUSIONS

The characteristic appearances of MP at the MH were attributed to MP in the plexiform layers and Müller cell cones. A central dip of MP distribution might be a sign of Müller cell cone damage that proceeds with MH formation.

TRANSLATIONAL RELEVANCE

Observation of MP was useful for understanding the mechanisms of MH formation.

摘要

目的

观察黄斑裂孔（MH）眼中的黄斑色素（MP）外观，并阐明其来源。基于 MP 的观察，讨论 MH 发展的机制。

方法

本观察性病例系列包括 31 例 33 只接受玻璃体切除术的 MH 患者的眼睛。使用双波长眼底自发荧光技术测量 MP 光密度。通过比较 MP 分布图像和光学相干断层扫描 B 扫描图像，评估 MP 的精确定位。

结果

MH 处的 MP 缺失。MP 缺陷区域与外丛状层缺陷区域相对应。在包括胶质（Müller 细胞）和丛状层的 2 期 MH 的视网膜瓣中以及在主要包含 Müller 细胞的 3 期 MH 的覆盖物中存在 MP。围绕 3 期和 4 期 MH 的外丛状层中的囊状空间在 MP 图像上呈现蜂窝状外观。MH 手术后，MP 重新出现并形成不规则形状的色素平面。手术前后 MP 光体积没有变化。伴有 MP 分布中央凹陷的对侧眼随后发生 MH。

结论

MH 处 MP 的特征外观归因于丛状层和 Müller 细胞锥体中的 MP。MP 分布中央凹陷可能是 Müller 细胞锥体损伤的标志，这与 MH 的形成有关。

翻译

杨雪

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/13478ff9a962/tvst-9-11-28-f009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/bb6638936ea4/tvst-9-11-28-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/21f3bed3a374/tvst-9-11-28-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/0f08261e9c58/tvst-9-11-28-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/80ab31a2a515/tvst-9-11-28-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/75e4400d2f1e/tvst-9-11-28-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/8e604dabdf4a/tvst-9-11-28-f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/53f922f78a25/tvst-9-11-28-f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/cc72a6f71e66/tvst-9-11-28-f008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/13478ff9a962/tvst-9-11-28-f009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/bb6638936ea4/tvst-9-11-28-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/21f3bed3a374/tvst-9-11-28-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/0f08261e9c58/tvst-9-11-28-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/80ab31a2a515/tvst-9-11-28-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/75e4400d2f1e/tvst-9-11-28-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/8e604dabdf4a/tvst-9-11-28-f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/53f922f78a25/tvst-9-11-28-f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/cc72a6f71e66/tvst-9-11-28-f008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b6/7594585/13478ff9a962/tvst-9-11-28-f009.jpg

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2
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3
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4
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