Ranabothu Saritha, Kanduri Swetha Rani, Nalleballe Krishna, Cheungpasitporn Wisit, Onteddu Sanjeeva, Kovvuru Karthik
Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA.
Nephrology, Ochsner Medical Center, New Orleans, USA.
Cureus. 2020 Nov 5;12(11):e11344. doi: 10.7759/cureus.11344.
The novel coronavirus disease 2019 (COVID-19) is a global pandemic affecting millions of people worldwide. Solid organ transplant (SOT) recipients are probably at higher risk of severe infection and associated complications from COVID-19. Data on clinical outcomes of COVID-19 infection in SOT recipients are limited. Using the TriNetX database, patients with laboratory-confirmed COVID-19 from January 20, 2020, to July 7, 2020, were included in the study. We compared clinical outcomes comprising hospitalization, need for critical care services, intubation, and mortality among SOT recipients and patients without SOT. Of 30,573 laboratory-confirmed COVID-19 patients, 288 had SOT. Patients with SOT were more likely to be hospitalized (37.2% vs. 12.2%; p < 0.0001), needed critical care services (6.9% vs. 2.3%; p < 0.0001), needed intubation (7.9% vs. 2.0%; p < 0.0001), and had a higher 30-day mortality (11.1% vs. 3.8%; p < 0.0001). Patients in the transplant group were older (55.4 vs. 47.6 years; p < 0.0001) and had a higher prevalence of medical co-morbidities. SOT recipients are at significant risk of adverse COVID-19 related outcomes, including hospitalization, need for critical care services, and 30-day mortality, likely due to multiple co-morbid conditions.
2019年新型冠状病毒病（COVID-19）是一场影响全球数百万人的大流行病。实体器官移植（SOT）受者感染COVID-19后发生严重感染及相关并发症的风险可能更高。关于SOT受者感染COVID-19的临床结局的数据有限。本研究使用TriNetX数据库，纳入了2020年1月20日至2020年7月7日实验室确诊为COVID-19的患者。我们比较了SOT受者和非SOT患者的临床结局，包括住院情况、重症监护服务需求、插管情况和死亡率。在30573例实验室确诊的COVID-19患者中，288例为SOT受者。SOT受者更有可能住院（37.2%对12.2%；p<0.0001）、需要重症监护服务（6.9%对2.3%；p<0.0001）、需要插管（7.9%对2.0%；p<0.0001），且30天死亡率更高（11.1%对3.8%；p<0.0001）。移植组患者年龄更大（55.4岁对47.6岁；p<0.0001），合并症患病率更高。SOT受者发生与COVID-19相关不良结局的风险显著，包括住院、需要重症监护服务和30天死亡率，这可能是由于多种合并症所致。
