Lin Panpan, Wang Manni, Wei Yuquan, Kim Taewan, Wei Xiawei
Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer Center National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu China.
Wexner Medical Center The Ohio State University Columbus Ohio 43210 USA.
MedComm (2020). 2020 Oct 1;1(3):270-301. doi: 10.1002/mco2.26. eCollection 2020 Dec.
Coronaviruses (CoVs), a subfamily of coronavirinae, are a panel of single-stranded RNA virus. Human coronavirus (HCoV) strains (HCoV-229E, HCoV-OC43, HCoV-HKU1, HCoV-NL63) usually cause mild upper respiratory diseases and are believed to be harmless. However, other HCoVs, associated with severe acute respiratory syndrome, Middle East respiratory syndrome, and COVID-19, have been identified as important pathogens due to their potent infectivity and lethality worldwide. Moreover, currently, no effective antiviral drugs treatments are available so far. In this review, we summarize the biological characters of HCoVs, their association with human diseases, and current therapeutic options for the three severe HCoVs. We also highlight the discussion about novel treatment strategies for HCoVs infections.
冠状病毒(CoVs)是冠状病毒亚科的一个分类,属于单链RNA病毒。人类冠状病毒(HCoV)毒株(HCoV - 229E、HCoV - OC43、HCoV - HKU1、HCoV - NL63)通常引起轻度上呼吸道疾病,被认为无害。然而,其他与严重急性呼吸综合征、中东呼吸综合征和新冠肺炎相关的人类冠状病毒,因其在全球范围内强大的传染性和致死率,已被确认为重要病原体。此外,目前尚无有效的抗病毒药物治疗方法。在本综述中,我们总结了人类冠状病毒的生物学特性、它们与人类疾病的关联,以及针对三种严重人类冠状病毒的当前治疗选择。我们还着重讨论了针对人类冠状病毒感染的新型治疗策略。