Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
Department of Oncology, Hematology and Transplantology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
Childs Nerv Syst. 2021 Apr;37(4):1243-1247. doi: 10.1007/s00381-020-04966-z. Epub 2020 Nov 10.
Horner syndrome (HS) manifests in unilateral ptosis, miosis, enophthalmos, and anhedonia. It is most commonly caused by trauma or surgical procedures, but can also occur in pediatric patients as a result of tumors, especially neuroblastoma (NBL). The objective of this study was to analyze the incidence of HS in patients diagnosed with NBL.
A retrospective analysis of data collected at the Department of Pediatric Oncology, Hematology, and Transplantology from 2004 to 2019 was performed. The study group included 119 patients younger than 18 years old, with 62 girls and 57 boys. All of them were diagnosed with a neuroblastic tumor.
Among the 119 patients, eight children (6.72%) were diagnosed with HS associated with NBL. Three of these patients presented to the clinic with HS, whereas HS developed after the surgical procedure to remove the tumor in four patients. The adrenal gland was the most frequent localization of the tumor. However, HS occurred more frequently in patients with mediastinum tumors. As a presenting symptom, HS occurred in 2 of 11 cases (18.18%) with mediastinum localization. All of the patients with HS were younger than 2 years old.
Investigation of the cause of isolated HS is crucial because it can be the first symptom of NBL. However, the surgical procedure itself increases the risk of HS as a complication of NBL treatment.
霍纳综合征（HS）表现为单侧上睑下垂、瞳孔缩小、眼球内陷和快感缺失。它最常见于创伤或手术引起，但也可发生于小儿患者，由肿瘤引起，尤其是神经母细胞瘤（NBL）。本研究的目的是分析诊断为 NBL 的患者中 HS 的发生率。
对 2004 年至 2019 年在儿科肿瘤学、血液学和移植学部收集的数据进行回顾性分析。研究组包括 119 名年龄小于 18 岁的患者，其中 62 名女孩和 57 名男孩。他们均被诊断为神经母细胞瘤。
在 119 名患者中，有 8 名儿童（6.72%）被诊断为与 NBL 相关的 HS。其中 3 名患儿以 HS 就诊，4 名患儿在肿瘤切除手术后出现 HS。肿瘤最常见的部位是肾上腺。然而，HS 在纵隔肿瘤患者中更为常见。作为首发症状，纵隔定位的 11 例中有 2 例（18.18%）出现 HS。所有患有 HS 的患者均小于 2 岁。
孤立性 HS 的病因调查至关重要，因为它可能是 NBL 的首发症状。然而，手术本身会增加 NBL 治疗并发症 HS 的风险。
