11 只临床健康猫总甲状腺素（T4）、游离 T4 和促甲状腺激素的生物学变异。
Biological variation of total thyroxine (T4), free T4 and thyroid-stimulating hormone in 11 clinically healthy cats.
机构信息
Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
出版信息
J Feline Med Surg. 2021 Jun;23(6):592-597. doi: 10.1177/1098612X20969485. Epub 2020 Nov 11.
OBJECTIVES
The aim of this study was to investigate the biological variation of total thyroxine (T4), free T4 (fT4) and thyroid-stimulating hormone (TSH) in 11 clinically healthy cats aged between 3 and 15 years old, in Sydney, Australia.
METHODS
Blood was collected weekly for up to 6 weeks and serum T4, fT4 and TSH concentrations were analysed using canine-specific reagents. Restricted maximum likelihood was used to estimate within-subject, between-subject and analytical variance components, which were recorded in terms of the related coefficients of variation. The index of individuality and reference change values were then calculated for each analyte.
RESULTS
T4 and TSH had intermediate individuality, indicating both subject-based and population-based reference intervals (RIs) could be used, with the knowledge that population-based RIs are suboptimally sensitive. fT4 had high individuality, indicating subject-based RIs are more appropriate than population-based RIs.
CONCLUSIONS AND RELEVANCE
This study has demonstrated that subject-based RIs could be more sensitive than population-based RIs for the diagnosis of thyroid dysfunction in cats.
目的
本研究旨在调查澳大利亚悉尼 11 只年龄在 3 至 15 岁之间的临床健康猫的总甲状腺素（T4）、游离甲状腺素（fT4）和促甲状腺激素（TSH）的生物学变异。
方法
每周采集血液，最长可达 6 周，并使用犬特异性试剂分析血清 T4、fT4 和 TSH 浓度。使用限制最大似然法估计个体内、个体间和分析变异分量，并以相关变异系数表示。然后计算每个分析物的个体指数和参考变化值。
结果
T4 和 TSH 具有中等的个体性，这表明可以使用基于个体的和基于群体的参考区间（RIs），但需要注意的是，基于群体的 RIs 的敏感性较差。fT4 具有高度的个体性，这表明基于个体的 RIs 比基于群体的 RIs 更合适。
结论和相关性
本研究表明，对于猫甲状腺功能障碍的诊断，基于个体的 RIs 可能比基于群体的 RIs 更敏感。
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