格陵兰雪橇犬（Canis lupus familiaris borealis）的甲状腺状态。

QimmeqHealth-thyroid status of Greenland sled dogs (Canis lupus familiaris borealis).

机构信息

Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 16, 1870, Frederiksberg C, Denmark.

出版信息

Acta Vet Scand. 2021 Nov 29;63(1):51. doi: 10.1186/s13028-021-00617-8.

DOI:10.1186/s13028-021-00617-8

PMID:34844628

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8630915/

Abstract

BACKGROUND

Greenland sled dogs (GSD) are a unique, genetically isolated population of dogs living under exceptional environmental conditions. Metabolism, and thereby thyroid hormones are affected by multiple factors. Among other activity, energy balance and environmental conditions are important. A breed-specific reference interval (RI) can be useful for diagnostics of potential thyroid-related pathologies. The aim of this study was to establish RIs of the thyroid hormones thyroxin (T4), free thyroxin (fT4), and thyroid stimulating hormone (TSH) in GSD. In addition to evaluate the effect of sex, age, season, management, and body condition score (BCS) in GSD. Physical exams and cephalic venous blood sampling were performed in the period of 2018-2019 from 265 GSD managed either privately or by the Danish navy. Serum biochemical analyses, including C-reactive protein, were performed and RIs were determined for TSH, T4 and fT4 in only healthy dogs. The RIs were determined using American Society for Veterinary Clinical Pathology guidelines and the effect of varying factors were evaluated by linear regression and further tested by Mann-Whitney test.

RESULTS

144 GSD were included in the reference group resulting in RIs: T4: 6.44-48.65 nmol/L; fT4: 3.91-18.51 pmol/L; and TSH: 0.04-0.55 ng/mL. Female GSD had significantly higher concentrations of T4 (P = 0.039) and fT4 (P = 0.015) compared to males; a positive correlation between TSH and aging was found; T4 concentrations were significantly higher (P = 0.003) during summer; and TSH concentrations were lower in GSD managed by the navy (P < 0.0001). BCS was higher (P < 0.0001) in Sirius GSD compared to civilian GSD, and BCS was positively correlated with T4 and negatively correlated with TSH.

CONCLUSIONS

Reference intervals for T4, fT4 and TSH in GSD were established. The RI for T4 and fT4 was lower compared to other breeds. In addition, sex, age, season, management and BCS demonstrated variable effects on thyroid hormones. Our results can be used as a foundation for improving management and further research of GSD.

摘要

背景

格陵兰雪橇犬（GSD）是一种独特的、遗传上隔离的犬种，生活在特殊的环境条件下。新陈代谢，从而甲状腺激素受多种因素影响。除了其他活动外，能量平衡和环境条件很重要。特定于品种的参考区间（RI）可用于诊断潜在的甲状腺相关病理。本研究的目的是建立 GSD 中甲状腺激素甲状腺素（T4）、游离甲状腺素（fT4）和促甲状腺激素（TSH）的 RI。此外，评估 GSD 中的性别、年龄、季节、管理和身体状况评分（BCS）的影响。在 2018-2019 年期间，对丹麦海军或私人管理的 265 只 GSD 进行了体格检查和头静脉采血。仅对健康犬进行了血清生化分析，包括 C 反应蛋白，并确定了 TSH、T4 和 fT4 的 RI。RI 是根据美国兽医临床病理学会的指南确定的，并通过线性回归评估了各种因素的影响，并进一步通过曼-惠特尼检验进行了检验。

结果

共有 144 只 GSD 被纳入参考组，得出的 RI 为：T4：6.44-48.65 nmol/L；fT4：3.91-18.51 pmol/L；和 TSH：0.04-0.55 ng/mL。与雄性相比，雌性 GSD 的 T4（P=0.039）和 fT4（P=0.015）浓度显著更高；发现 TSH 与年龄呈正相关；T4 浓度在夏季显著升高（P=0.003）；并且海军管理的 GSD 的 TSH 浓度较低（P<0.0001）。与民用 GSD 相比， Sirius GSD 的 BCS 更高（P<0.0001），BCS 与 T4 呈正相关，与 TSH 呈负相关。