Foreman D, Zuk L, Miller D B, Salomon R G
Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106.
Prostaglandins. 1987 Jul;34(1):91-8. doi: 10.1016/0090-6980(87)90266-8.
The effects of E2 levuglandins on the contractile activity of rat uterine horns were studied. LGE2, AnLGE2, delta 9-LGE2 and the synthetic epimer, 8-epi-delta 9-LGE2 all induced contractions in a dose-response fashion. AnLGE2 gave decreased responses with increased bath concentrations. Paired comparisons showed potent and selective inhibitory effects of AnLGE2 on the uterotonic activity of prostaglandins. AnLGE2 inhibited the uterotonic activity of PGE2 at a 0.1:1 ratio, of PGD2 at a 1:1 ratio, but did not inhibit the activity of PGF2 alpha. Exposure of spontaneously contracting uteri to high concentrations of AnLGE2, or prolonged exposure to lower concentrations, suppressed contractions.
研究了E2-列腺素对大鼠子宫角收缩活性的影响。LGE2、AnLGE2、δ9-LGE2和合成差向异构体8-表-δ9-LGE2均以剂量反应方式诱导收缩。随着浴液浓度增加，AnLGE2的反应减弱。配对比较显示AnLGE2对前列腺素子宫收缩活性有强效和选择性抑制作用。AnLGE2以0.1:1的比例抑制PGE2的子宫收缩活性，以1:1的比例抑制PGD2的子宫收缩活性，但不抑制PGF2α的活性。将自发收缩的子宫暴露于高浓度的AnLGE2，或长时间暴露于低浓度的AnLGE2，均会抑制收缩。
