前列环素（PGI2）及其代谢产物6-氧代前列腺素F1α（6-oxo-PGF1α）对人子宫和输卵管的药理活性。

Pharmacological activity of PGI2 and its metabolite 6-oxo-PGF1alpha on human uterus and fallopian tubes.

作者信息

Omini C, Pasargiklian R, Folco G C, Fano M, Berti F

出版信息

Prostaglandins. 1978 Jun;15(6):1045-54. doi: 10.1016/0090-6980(78)90047-3.

Abstract

The actions of prostacyclin (PGI2) and its stable metabolite 6-OXO-PGF1alpha were investigated in strips of normal human uterus and in fallopian tubes. Both compounds were also compared with natural prostaglandins (PGE2, PGF2alpha and PGD2). PGI2 showed biphasic response both in uterus and fallopian tubes qualitatively and quantitatively similar to that induced by PGE2 and PGD2; prostacyclin was also able to inhibit the spasmus induced by PGF2alpha but not that induced by BaCl2 and vasopressin. 6-0XO-PGF1alpha on the other hand induced only small contractions on both tissues investigated. The authors discusse the possible implication of these findings in the physiology of the reproductive system.

摘要

在正常人体子宫和输卵管组织条上研究了前列环素（PGI2）及其稳定代谢产物6-氧代-PGF1α的作用。这两种化合物还与天然前列腺素（PGE2、PGF2α和PGD2）进行了比较。PGI2在子宫和输卵管中均表现出双相反应，在定性和定量方面与PGE2和PGD2诱导的反应相似；前列环素也能够抑制PGF2α诱导的痉挛，但不能抑制BaCl2和血管加压素诱导的痉挛。另一方面，6-氧代-PGF1α在所研究的两种组织上仅引起轻微收缩。作者讨论了这些发现对生殖系统生理学可能的影响。