父系血统塑造精液概念：循环因子作为跨代“表观遗传病变”和“表观遗传弹性”的介质。
Paternal bloodlines sculpting seminal concepts: circulating factors as mediators of transgenerational 'epigenopathy' and 'epigenetic resilience'.
机构信息
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic., Australia.
Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Vic., Australia.
出版信息
EMBO J. 2020 Dec 1;39(23):e107014. doi: 10.15252/embj.2020107014. Epub 2020 Nov 11.
Abstract
Accumulating evidence, particularly from rodent and human studies, shows that the environmental exposures and experience of a father prior to conception can modulate sperm epigenetics and subsequent offspring phenotypes. In this issue of The EMBO Journal, van Steenwyk and colleagues (2020) provide important new insights into how one form of paternal experience (early-life stress or trauma) may impact sperm epigenetics via circulating factors, presenting novel experimental evidence from a mouse model and an analogous human cohort.
摘要
越来越多的证据表明，特别是来自啮齿动物和人类的研究，父亲在受孕前的环境暴露和经历可以调节精子的表观遗传学，并影响后代的表型。在本期《EMBO 杂志》中，van Steenwyk 及其同事提供了重要的新见解，说明了一种父体经历（早期生活压力或创伤）如何通过循环因子影响精子的表观遗传学，提出了来自小鼠模型和类似人类队列的新实验证据。
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