Dermatology, Venereology and Andrology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Dermatology, Venereology and Andrology Department, Misr University for Science and Technology, 6th of October City, Egypt.
J Cosmet Dermatol. 2021 Jul;20(7):2240-2246. doi: 10.1111/jocd.13831. Epub 2020 Nov 25.
Homologous autoinoculation is a novel minimally invasive procedure that treats warts by stimulating specific immune response.
To evaluate the efficacy and safety of autoinoculation in treatment of multiple recalcitrant warts of different types in relation to patient's age, gender, type, number, size, and duration of warts.
Two hundred patients with multiple recalcitrant warts of different types were treated with one autoinoculation session. Each patient was subjected to history taking, general and dermatological examination, and photographic documentation before and after treatment. Patients were followed up after 1 week, 2, 12, and 16 weeks to assess possible side effects, treatment response, and recurrence rate, respectively. Evaluation of treatment response was done through physician assessment according to change in size or number of warts or both.
After 12 weeks of procedure, 66% of patients showed complete clearance, 26% showed moderate clearance, and 4% showed mild clearance while only 1.5% of patients showed treatment failure, with negligible side effects and no recurrence. There was negative correlation between treatment response and wart duration (P < .001).
Autoinoculation is effective in treating multiple recalcitrant warts irrespective of their type, number or size, with minimal complications and no recurrence. The longer wart duration is, the less treatment response will be achieved.
同源自体接种是一种新颖的微创治疗方法，通过刺激特异性免疫反应来治疗疣。
评估自体接种治疗不同类型、多发性顽固性疣的疗效和安全性，与患者的年龄、性别、类型、数量、大小和疣的持续时间有关。
200 例不同类型多发性顽固性疣患者接受一次自体接种治疗。每位患者在治疗前后均进行病史采集、一般和皮肤科检查以及照相记录。在治疗后 1 周、2 周、12 周和 16 周分别进行随访，以评估可能的副作用、治疗反应和复发率。治疗反应的评估是通过医生根据疣的大小或数量或两者的变化来进行评估。
在治疗 12 周后，66%的患者完全清除，26%的患者中度清除，4%的患者轻度清除，只有 1.5%的患者治疗失败，副作用极小，无复发。治疗反应与疣持续时间呈负相关（P<.001）。
自体接种治疗多发性顽固性疣有效，无论其类型、数量或大小如何，并发症少，无复发。疣的持续时间越长，治疗反应越差。
