School of Biological Sciences, Monash University, Australia.
School of Biological Sciences, Monash University, Australia.
Curr Opin Biotechnol. 2021 Apr;68:89-95. doi: 10.1016/j.copbio.2020.09.016. Epub 2020 Nov 8.
The concept of (bacterio)phage therapy is simple; target the phage to the bacterial pathogen causing disease. As phages are natural killers of bacteria, one could expect this to be an easy task. However, when it comes to phage therapy within the gut, it might not be quite that simple. Already without exogenous intervention, a multitude of phage-bacterial interactions occur within the human gut, some of which might play a direct role in disease progression. In this perspective, we aim to summarise the current understanding of phages within our gut, moving from infancy, adulthood, and then into disease progression. We then highlight recent advances in phage-based interventions, both conventional phage therapy and the progressing field of whole virome transplant.
噬菌体治疗的概念很简单；将噬菌体靶向导致疾病的细菌病原体。由于噬菌体是细菌的天然杀手，人们可能会认为这是一项简单的任务。然而，当涉及到肠道内的噬菌体治疗时，情况可能并不那么简单。即使没有外源干预，人类肠道内也会发生多种噬菌体-细菌相互作用，其中一些可能直接参与疾病的进展。在这个观点中，我们旨在总结目前对我们肠道内噬菌体的理解，从婴儿期、成年期，然后到疾病进展。然后，我们强调了基于噬菌体的干预措施的最新进展，包括传统的噬菌体治疗和正在发展的全病毒组移植领域。
