Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Thailand.
Allergy and Rheumatology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, HatYai, Thailand.
Lupus. 2021 Feb;30(2):352-359. doi: 10.1177/0961203320973072. Epub 2020 Nov 11.
Systemic lupus erythematosus (SLE) is a chronic disease requiring complex treatment strategies to prevent disease flare ups and to reduce hospitalizations. Medication adherence is the main concern for improving patient outcomes. Although various studies on medication nonadherence for SLE have been conducted, no definite conclusions have been reached.
To quantify the prevalence of medication nonadherence among patients with SLE and to analyse the associated factors.
A prospective, self-reported questionnaire study was conducted in Songklanagarind Hospital. Patient aged 18 years or older, who had an established diagnosis of SLE, and who had been receiving medications for at least 6 months, were included in the study. Medication adherence was assessed through a visual analogue scale (VAS) and through the medication-taking behaviour measure for Thai patients (MTB-Thai) scale.
One hundred and seventy-two SLE patients were enrolled in the study. Most SLE patients were young to middle aged (56.40%) and had no clinical disease activity (67.4%), as assessed by a clinical SLEDAI score. Nonadherence rates were 32% and 25.3% by VAS and the MTB-Thai scale, respectively. Patients aged 55 years or older, who used the universal coverage of health care system, who used multiple medications (>10 pills/day), and who had a good attitude towards the disease were associated with a low risk of nonadherence.
Up to 25% SLE patients poorly adhered to their prescriptions. Age, reimbursement scheme, pill number, and attitude towards SLE were associated with nonadherence in our patients with SLE.
系统性红斑狼疮（SLE）是一种慢性病，需要复杂的治疗策略来预防疾病发作和减少住院治疗。药物依从性是改善患者预后的主要关注点。尽管已经进行了多项关于 SLE 患者药物不依从性的研究，但尚未得出明确的结论。
量化 SLE 患者药物不依从的发生率，并分析相关因素。
在宋卡王子大学医院进行了一项前瞻性、自我报告的问卷调查研究。纳入年龄在 18 岁及以上、已确诊为 SLE 且至少接受 6 个月药物治疗的患者。通过视觉模拟量表（VAS）和泰国患者用药行为量表（MTB-Thai）评估药物依从性。
共纳入 172 例 SLE 患者。大多数 SLE 患者为中青年（56.40%），根据临床 SLEDAI 评分，无临床疾病活动（67.4%）。VAS 和 MTB-Thai 量表评估的不依从率分别为 32%和 25.3%。年龄在 55 岁及以上、使用全民健康覆盖计划、使用多种药物（>10 片/天）以及对疾病持良好态度的患者，药物不依从的风险较低。
多达 25%的 SLE 患者不遵医嘱服药。年龄、报销方案、服药数量和对 SLE 的态度与我们的 SLE 患者的不依从有关。
