School of Nursing, Nantong University, Nantong, China.
From the Department of Nursing, The Second Affiliated Hospital of Nantong University.
J Clin Rheumatol. 2020 Apr;26(3):94-98. doi: 10.1097/RHU.0000000000000952.
Medication adherence plays an important role in improving symptoms and ameliorating the progression of systemic lupus erythematosus (SLE). The purpose of this study was to examine the medication adherence rate and explore the related factors for nonadherence in Chinese SLE patients.
A cross-sectional study from The Second Affiliated Hospital of Nantong University between January 2017 and February 2018 was conducted. Patients with SLE completed the Compliance Questionnaire on Rheumatology to evaluate adherence, the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) for disease activity, and the Hospital Anxiety and Depression Scale to assess anxiety and depression. χ Analyses, independent samples t tests, and logistic regression models were used to analyze data.
This study included 144 SLE patients, and we found that 43.1% (n = 62) of the patients were nonadherence. Education, SLEDAI, anxiety, and depression were correlated with adherence in SLE patients. Moreover, logistic regression models identified education, SLEDAI, and depression as important associated factors of nonadherence.
This is the first time to evaluate demographic, clinical, and psychological related factors for medication adherence in Chinese SLE patients using SLEDAI and Hospital Anxiety and Depression Scale. Our study showed that 56.9% of SLE patients were not adherent, and education, SLEDAI, and depression were significantly related to medication adherence in SLE. These findings suggested that it was necessary to pay more attention to medication adherence of SLE patients, especially those with lower level of education, higher score of SLEDAI, and depression by effective intervention to improve SLE patients' adherence, so as to improve their quality of life.
药物依从性在改善系统性红斑狼疮（SLE）患者症状和延缓疾病进展方面起着重要作用。本研究旨在调查中国 SLE 患者的药物依从性及其相关因素。
2017 年 1 月至 2018 年 2 月在南通大学第二附属医院进行了一项横断面研究。SLE 患者完成了风湿病依从性问卷以评估依从性、SLE 疾病活动指数（SLEDAI）以评估疾病活动度、医院焦虑抑郁量表以评估焦虑和抑郁。采用卡方检验、独立样本 t 检验和逻辑回归模型进行数据分析。
本研究共纳入 144 例 SLE 患者，其中 43.1%（n=62）的患者不依从。教育程度、SLEDAI、焦虑和抑郁与 SLE 患者的依从性相关。此外，逻辑回归模型确定教育程度、SLEDAI 和抑郁是不依从的重要相关因素。
这是首次使用 SLEDAI 和医院焦虑抑郁量表评估中国 SLE 患者的人口统计学、临床和心理相关因素对药物依从性的影响。本研究表明，56.9%的 SLE 患者不依从，教育程度、SLEDAI 和抑郁与 SLE 患者的药物依从性显著相关。这些发现表明，有必要通过有效的干预措施关注 SLE 患者的药物依从性，尤其是那些教育程度较低、SLEDAI 评分较高和抑郁的患者，以提高 SLE 患者的依从性，从而提高其生活质量。
