Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London, UK.
Cambridge Vascular Unit, Cambridge University Hospitals NHS Trust, Addenbrookes Hospital, Cambridge, UK.
Phlebology. 2021 May;36(4):290-302. doi: 10.1177/0268355520968640. Epub 2020 Nov 11.
This randomised controlled trial investigates the dosing effect of neuromuscular electrical stimulation (NMES) in patients with chronic venous disease (CVD).
Seventy-six patients with CEAP C3-C5 were randomised to Group A (no NMES), B (30 minutes of NMES daily) or C (60 minutes of NMES daily). Primary outcome was percentage change in Femoral Vein Time Averaged Mean Velocity (TAMV) at 6 weeks. Clinical severity scores, disease-specific and generic quality of life (QoL) were assessed.
Seventy-six patients were recruited - mean age 60.8 (SD14.4) and 47:29 male. Six patients lost to follow-up. Percentage change in TAMV (p<0.001) was significantly increased in Groups B and C. Aberdeen Varicose Veins Questionnaire Score (-6.9, p=0.029) and Venous Clinical Severity Score (-4, p-0.003) improved in Group C, and worsened in Group A (+1, p=0.025).
Daily NMES usage increases flow parameters, with twice daily usage improving QoL and clinical severity at 6 weeks in CVD patients.
本随机对照试验研究了神经肌肉电刺激（NMES）在慢性静脉疾病（CVD）患者中的剂量效应。
76 例 CEAP C3-C5 的患者被随机分为 A 组（无 NMES）、B 组（每天 30 分钟 NMES）或 C 组（每天 60 分钟 NMES）。主要结局是 6 周时股静脉平均流速（TAMV）的百分比变化。评估了临床严重程度评分、疾病特异性和一般生活质量（QoL）。
共招募了 76 例患者，平均年龄 60.8（SD14.4）岁，男女比例为 47:29。6 例患者失访。B 组和 C 组的 TAMV 百分比变化（p<0.001）显著增加。C 组的阿伯丁静脉曲张问卷评分（-6.9，p=0.029）和静脉临床严重程度评分（-4，p-0.003）改善，而 A 组则恶化（+1，p=0.025）。
每天使用 NMES 可增加血流参数，在 CVD 患者中，每天两次使用 NMES 可在 6 周时改善 QoL 和临床严重程度。
