Department of Pharmaceutics, Dr. D.Y. Patil Institute of Pharamceutical Sciences and Research, Pune, Maharashtra 411018, India.
ThinCR Technologies India Pvt Ltd, Rahatani, Pune, Maharashtra 411017, India.
Curr Drug Deliv. 2021;18(4):387-407. doi: 10.2174/1567201817999201110193655.
Hot Melt Extrusion (HME) is a continuous pharmaceutical manufacturing process that has been extensively investigated for solubility improvement and taste masking of active pharmaceutical ingredients. Recently, it is being explored for its application in 3D printing. 3D printing of pharmaceuticals allows flexibility of dosage form design, customization of dosage form for personalized therapy and the possibility of complex designs with the inclusion of multiple actives in a single unit dosage form. Fused Deposition Modeling (FDM) is a 3D printing technique with a variety of applications in pharmaceutical dosage form development. FDM process requires a polymer filament as the starting material that can be obtained by hot melt extrusion. Recent reports suggest enormous applications of a combination of hot melt extrusion and FDM technology in 3D printing of pharmaceuticals and need to be investigated further. This review in detail describes the HME process, along with its application in 3D printing. The review also summarizes the published reports on the application of HME coupled with 3D printing technology in drug delivery.
热熔挤出（HME）是一种连续的制药生产工艺，已广泛研究用于提高活性药物成分的溶解度和掩味。最近，它在 3D 打印中的应用也在被探索。药物的 3D 打印允许剂型设计的灵活性、针对个性化治疗的剂型定制以及在单个单位剂型中包含多种活性成分的复杂设计的可能性。熔融沉积成型（FDM）是一种 3D 打印技术，在药物剂型开发中有多种应用。FDM 工艺需要聚合物长丝作为起始材料，而聚合物长丝可以通过热熔挤出获得。最近的报告表明，热熔挤出和 FDM 技术的组合在药物 3D 打印中有巨大的应用，需要进一步研究。本综述详细描述了 HME 工艺及其在 3D 打印中的应用。该综述还总结了关于 HME 与 3D 打印技术在药物传递中的应用的已发表报告。
