Cunha-Filho Marcilio, Araújo Maísa Rp, Gelfuso Guilherme M, Gratieri Tais
Laboratory of Food, Drug & Cosmetics (LTMAC), School of Health Sciences, University of Brasília (UnB), 70.910-900, Brasília, DF, Brazil.
Ther Deliv. 2017 Nov;8(11):957-966. doi: 10.4155/tde-2017-0067.
The production process of 3D-printed drugs offers unique advantages such as the possibility of individualizing the drug therapy and easily associating different drugs and release technologies in the same pharmaceutical unit. Fused deposition modeling, a 3D printing technique, seems especially interesting for pharmaceutical applications, due to its low cost, precise and reproducible control of the printed structures, and versatility for industrial and laboratory scale. This technique combined with another technology already adapted for the pharmaceutical industry, the hot melt extrusion, is able to incorporate various mechanisms of modified drug release. This special report aims to bring together data of the experimental progress achieved using the fused deposition modeling 3D printing combined with hot melt extrusion technique and its potential in drug delivery. [Formula: see text].
3D打印药物的生产过程具有独特优势，例如能够实现药物治疗的个体化，并且可以轻松地在同一药物单元中结合不同药物和释放技术。熔融沉积建模作为一种3D打印技术，因其成本低、对打印结构的精确且可重复控制以及在工业和实验室规模上的通用性，在药物应用方面似乎特别有吸引力。该技术与另一种已适用于制药行业的技术——热熔挤出相结合，能够纳入各种药物缓释机制。本专题报告旨在汇集使用熔融沉积建模3D打印与热熔挤出技术相结合所取得的实验进展数据及其在药物递送方面的潜力。[公式：见正文]
