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线粒体靶向乏氧型氟碳纳米粒用于成像指导肿瘤光热治疗

Mitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy.

机构信息

Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.

Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.

出版信息

Int J Nanomedicine. 2020 Nov 5;15:8641-8658. doi: 10.2147/IJN.S281649. eCollection 2020.

DOI:10.2147/IJN.S281649
PMID:33177823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7652575/
Abstract

BACKGROUND: Although photothermal therapy (PTT) and photodynamics therapy (PDT) have both made excellent progress in tumor therapy, the effectiveness of using PTT or PDT alone is dissatisfactory due to the limitations of the penetration depth in PTT and the hypoxic microenvironment of tumors for PDT. Combination phototherapy has currently become a burgeoning cancer treatment. METHODS AND MATERIALS: In this work, a mitochondria-targeting liquid perfluorocarbon (PFC)-based oxygen delivery system was developed for the synergistic PDT/photothermal therapy (PTT) of cancer through image guiding. RESULTS: Importantly, these nanoparticles (NPs) can effectively and accurately accumulate in the target tumor via the enhanced permeability and retention (EPR) effect. CONCLUSION: This approach offers a novel technique to achieve outstanding antitumor efficacy by an unprecedented design with tumor mitochondria targeting, oxygen delivery, and synergistic PDT/PTT with dual-imaging guidance.

摘要

背景：尽管光热疗法（PTT）和光动力疗法（PDT）在肿瘤治疗方面都取得了优异的进展，但由于 PTT 的穿透深度限制和 PDT 的肿瘤缺氧微环境限制，单独使用 PTT 或 PDT 的效果并不理想。组合光疗目前已成为一种新兴的癌症治疗方法。

方法和材料：在这项工作中，通过图像引导，开发了一种靶向线粒体的液体全氟碳（PFC）氧输送系统，用于癌症的协同 PDT/光热治疗（PTT）。

结果：重要的是，这些纳米颗粒（NPs）可以通过增强的通透性和保留（EPR）效应有效地、准确地在靶肿瘤中积累。

结论：通过靶向肿瘤线粒体、供氧以及具有双重成像指导的协同 PDT/PTT 的前所未有的设计，这种方法为实现优异的抗肿瘤疗效提供了一种新的技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/b5948cc68db9/IJN-15-8641-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/32a47da3f313/IJN-15-8641-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/ede9e6efe483/IJN-15-8641-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/8005696c620d/IJN-15-8641-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/b5012b18dae4/IJN-15-8641-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/4bd5c74681ad/IJN-15-8641-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/f7badc1acfd9/IJN-15-8641-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/ad7d16e2e84b/IJN-15-8641-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/e5484e5045b4/IJN-15-8641-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/70481c73db00/IJN-15-8641-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/b5948cc68db9/IJN-15-8641-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/32a47da3f313/IJN-15-8641-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/ede9e6efe483/IJN-15-8641-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/8005696c620d/IJN-15-8641-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/b5012b18dae4/IJN-15-8641-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/4bd5c74681ad/IJN-15-8641-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/f7badc1acfd9/IJN-15-8641-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/ad7d16e2e84b/IJN-15-8641-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/e5484e5045b4/IJN-15-8641-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/70481c73db00/IJN-15-8641-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf0/7652575/b5948cc68db9/IJN-15-8641-g0010.jpg

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本文引用的文献

[1]
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Biomaterials. 2020-2

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Adv Mater. 2019-9-30

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Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells.

Adv Mater. 2019-3-27

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Multifunctional Thermosensitive Liposomes Based on Natural Phase-Change Material: Near-Infrared Light-Triggered Drug Release and Multimodal Imaging-Guided Cancer Combination Therapy.

ACS Appl Mater Interfaces. 2019-3-8

[10]
Mitochondria-Targeted and Ultrasound-Activated Nanodroplets for Enhanced Deep-Penetration Sonodynamic Cancer Therapy.

ACS Appl Mater Interfaces. 2019-2-20

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