Hossain Md Farhad, Hasana Sharifa, Mamun Abdullah Al, Uddin Md Sahab, Wahed Mir Imam Ibne, Sarker Sabarni, Behl Tapan, Ullah Irfan, Begum Yesmin, Bulbul Israt Jahan, Amran Md Shah, Rahman Md Habibur, Bin-Jumah May N, Alkahtani Saad, Mousa Shaker A, Aleya Lotfi, Abdel-Daim Mohamed M
Department of Physical Therapy, Graduate School of Inje University, Gimhae, South Korea.
Pharmakon Neuroscience Research Network, Dhaka, Bangladesh.
Front Pharmacol. 2020 Oct 16;11:563478. doi: 10.3389/fphar.2020.563478. eCollection 2020.
At the end of 2019, a novel coronavirus (CoV) was found at the seafood market of Hubei province in Wuhan, China, and this virus was officially named coronavirus diseases 2019 (COVID-19) by World Health Organization (WHO). COVID-19 is mainly characterized by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and creates public health concerns as well as significant threats to the economy around the world. Unfortunately, the pathogenesis of COVID-19 is unclear and there is no effective treatment of this newly life-threatening and devastating virus. Therefore, it is crucial to search for alternative methods that alleviate or inhibit the spread of COVID-19. In this review, we try to find out the etiology, epidemiology, symptoms as well as transmissions of this novel virus. We also summarize therapeutic interventions and suggest antiviral treatments, immune-enhancing candidates, general supplements, and CoV specific treatments that control replication and reproduction of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV).
2019年底，在中国武汉湖北省的海鲜市场发现了一种新型冠状病毒（CoV），该病毒被世界卫生组织（WHO）正式命名为2019冠状病毒病（COVID-19）。COVID-19主要由严重急性呼吸综合征冠状病毒2（SARS-CoV2）引起，对全球公共卫生构成了威胁，并对世界经济造成了重大影响。不幸的是，COVID-19的发病机制尚不清楚，对于这种新出现的危及生命且具有破坏性的病毒，目前尚无有效的治疗方法。因此，寻找减轻或抑制COVID-19传播的替代方法至关重要。在这篇综述中，我们试图找出这种新型病毒的病因、流行病学、症状以及传播方式。我们还总结了治疗干预措施，并提出了抗病毒治疗、免疫增强候选药物、一般补充剂以及控制SARS-CoV和中东呼吸综合征冠状病毒（MERS-CoV）复制和繁殖的针对冠状病毒的特异性治疗方法。
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