Lee Na Yeong, Han Kyungdo, Lee Yoonji, Kim Seulki, Lee Seonhwa, Choi Yujung, Ahn Moon Bae, Kim Shin Hee, Cho Won Kyoung, Cho Kyoung Soon, Jung Min Ho, Park Yong-Gyu, Suh Byung-Kyu
Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Int J Endocrinol. 2020 Oct 30;2020:8737912. doi: 10.1155/2020/8737912. eCollection 2020.
Little information is available on the association between parents' metabolic syndrome (MetS) and adolescent offspring's obesity in Korea. The aim of our study is to determine the association between parent's metabolic syndrome and offspring's obesity.
The study data were obtained from the Korean National Health and Nutrition Examination Survey conducted during 2009-2016. In the present study, 3140 adolescents aged 12 to 18 years, their paternal pairs (PP, fathers = 2244), and maternal pairs (MP, mothers = 3022) were analyzed. Of these 3140 adolescents, 2637 had normal weight {age- and sex-specific body mass index (BMI) under the 85 percentile}, whereas 467 were overweight (age- and sex-specific BMI over the 85 percentile).
Offspring's overweight and central obesity were associated with all components of the PP's metabolic risk factors, including central obesity ( < 0.001), systolic ( < 0.001) and diastolic blood pressure ( < 0.001), glucose intolerance ( < 0.001), and triglyceride ( < 0.002) and high-density lipoprotein levels (=0.049). In addition, offspring's overweight and central obesity were also associated with the metabolic risk factors of MP, including central obesity ( < 0.001), systolic ( < 0.001) and diastolic blood pressure ( < 0.001), glucose intolerance ( < 0.001), and triglyceride levels ( < 0.001). In multivariate logistic regression analysis, offspring's overweight was significantly and positively associated with parental central obesity (PP, adjusted odds ratio (OR) = 1.593; 95% confidence interval (CI): 1.192-2.128; MP, adjusted OR = 2.221, 95% CI: 1.755-2.812) and parental metabolic syndrome (PP, adjusted OR = 2.032; 95% CI: 1.451-2.846; MP, adjusted OR = 2.972, 95% CI: 2.239-3.964). As the number of parental metabolic risk factors increased, offspring's risk for overweight and central obesity increased ( for trends < 0.001).
Parental metabolic syndrome was associated with obesity in 12- to 18-year-old offspring in Korea.
在韩国，关于父母的代谢综合征（MetS）与青少年后代肥胖之间的关联，目前所知信息较少。我们研究的目的是确定父母的代谢综合征与后代肥胖之间的关联。
研究数据取自2009年至2016年期间进行的韩国国家健康与营养检查调查。在本研究中，分析了3140名12至18岁的青少年、他们的父系对（PP，父亲 = 2244人）和母系对（MP，母亲 = 3022人）。在这3140名青少年中，2637人体重正常{年龄和性别特异性体重指数（BMI）低于第85百分位数}，而467人超重（年龄和性别特异性BMI高于第85百分位数）。
后代超重和中心性肥胖与父系代谢危险因素的所有组分相关，包括中心性肥胖（<0.001）、收缩压（<0.001）和舒张压（<0.001）、葡萄糖耐量异常（<0.001）、甘油三酯（<0.002）和高密度脂蛋白水平（=0.049）。此外，后代超重和中心性肥胖也与母系代谢危险因素相关，包括中心性肥胖（<0.001）、收缩压（<0.001）和舒张压（<0.001）、葡萄糖耐量异常（<0.001）和甘油三酯水平（<0.001）。在多因素逻辑回归分析中，后代超重与父母的中心性肥胖显著正相关（PP，调整后的优势比（OR）=1.593；95%置信区间（CI）：1.192 - 2.128；MP，调整后的OR = 2.221，95%CI：1.755 - 2.812）以及父母的代谢综合征（PP，调整后的OR = 2.032；95%CI：1.451 - 2.846；MP，调整后的OR = 2.972，95%CI：2.239 - 3.964）。随着父母代谢危险因素数量的增加，后代超重和中心性肥胖的风险增加（趋势<0.001）。
在韩国，父母的代谢综合征与12至18岁后代的肥胖相关。
