Liu Han-Chao, Xie Yun, Deng Chun-Hua, Liu Gui-Hua
Department of Andrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
Reproductive Medicine Research Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China.
World J Stem Cells. 2020 Oct 26;12(10):1097-1112. doi: 10.4252/wjsc.v12.i10.1097.
With the decline in male fertility in recent years, strategies for male fertility preservation have received increasing attention. In this study, by reviewing current treatments and recent publications, we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation, focusing on the use of spermatogonial stem cells (SSCs), SSC niches, SSC-based testicular organoids, other stem cell types such as mesenchymal stem cells, and stem cell-derived extracellular vesicles. In conclusion, a more comprehensive understanding of the germ cell microenvironment, stem cell-derived extracellular vesicles, and testicular organoids will play an important role in achieving male fertility preservation.
近年来，随着男性生育能力的下降，男性生育力保存策略受到了越来越多的关注。在本研究中，通过回顾当前的治疗方法和近期的出版物，我们描述了基于干细胞的男性生育力保存疗法的研究进展和未来方向，重点关注精原干细胞（SSCs）、SSC微环境、基于SSC的睾丸类器官、其他干细胞类型（如间充质干细胞）以及干细胞衍生的细胞外囊泡的应用。总之，更全面地了解生殖细胞微环境、干细胞衍生的细胞外囊泡和睾丸类器官将在实现男性生育力保存方面发挥重要作用。
