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[宋内氏菌和霍乱弧菌毒素在小鼠小肠孤立肠袢中的试验]

[Trial of the toxins of the Sonne microbe and cholera vibrio in an isolated loop of mouse small intestine].

作者信息

Kamzolkina N B, Karaeva L T, Dzhaparidze M N, Kokorina T A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1977 Jun(6):84-8.

PMID:331786
Abstract

Enterotoxic properties of neuro-and endotoxins of Sonne dysentery bacillus, of cholerogen, and Bowen's cholera vibrio endotoxin were determined on a model of an isolated loop of the mouse small intestine. In definite doses all the mentioned preparations could induce dilatation of the isolated loop of the mouse small intestine. In case of Sonne bacillus neurotoxin this property correlated with the toxicity of the preparation for the animals and failed to depend on the virulence and biochemical reference of the strain from which it was obtained. Marked variations in the sensitivity of mongrel and linear mice to the mentioned preparations were noted.

摘要

利用小鼠小肠孤立肠袢模型测定了宋内痢疾杆菌的神经毒素和内毒素、霍乱肠毒素以及鲍氏霍乱弧菌内毒素的肠毒素特性。所有上述制剂在一定剂量下均可引起小鼠小肠孤立肠袢扩张。就宋内杆菌神经毒素而言,此特性与制剂对动物的毒性相关,且不取决于产生该毒素的菌株的毒力和生化指标。观察到杂种小鼠和品系小鼠对上述制剂的敏感性存在显著差异。

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