Bhoopalam Myan, Garza Luis A, Reddy Sashank K
Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Front Cell Dev Biol. 2020 Oct 15;8:582346. doi: 10.3389/fcell.2020.582346. eCollection 2020.
Hair follicles are the signature dermal appendage of mammals. They can be thought of as mini-organs with defined polarity, distinct constituent cell types, dedicated neurovascular supply, and specific stem cell compartments. Strikingly, some mammals show a capacity for adult hair follicle regeneration in a phenomenon known as wound-induced hair neogenesis (WIHN). In WIHN functional hair follicles reemerge during healing of large cutaneous wounds, and they can be counted to provide an index of regeneration. While age-related decline in hair follicle number and cycling are widely appreciated in normal physiology, it is less clear whether hair follicle regeneration also diminishes with age. WIHN provides an extraordinary quantitative system to address questions of mammalian regeneration and aging. Here we review cellular and molecular underpinnings of WIHN, explore known age-related changes to these elements, and present unanswered questions for future exploration.
毛囊是哺乳动物特有的皮肤附属器。它们可被视为具有明确极性、不同组成细胞类型、专门的神经血管供应和特定干细胞区室的微型器官。引人注目的是，一些哺乳动物表现出成年毛囊再生的能力，即所谓的伤口诱导毛发新生（WIHN）现象。在WIHN过程中，功能性毛囊在大型皮肤伤口愈合期间重新出现，并且可以通过计数来提供再生指标。虽然在正常生理状态下，毛囊数量和周期性的年龄相关下降已广为人知，但毛囊再生是否也会随着年龄增长而减少尚不清楚。WIHN提供了一个非凡的定量系统，以解决哺乳动物再生和衰老的问题。在此，我们综述WIHN的细胞和分子基础，探讨这些因素已知的与年龄相关的变化，并提出有待未来探索的未解决问题。
