干细胞在创伤愈合过程中的动力学、迁移和可塑性。
Stem cell dynamics, migration and plasticity during wound healing.
机构信息
Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium.
WELBIO, Université Libre de Bruxelles, Brussels, Belgium.
出版信息
Nat Cell Biol. 2019 Jan;21(1):18-24. doi: 10.1038/s41556-018-0237-6. Epub 2019 Jan 2.
Abstract
Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem cells recruited from various skin regions together with other cell types, including fibroblasts and immune cells, is required to ensure efficient and harmonious wound healing. A complex crosstalk ensures the activation, migration and plasticity of these cells during tissue repair.
摘要
组织修复对于动物的生存至关重要。皮肤表皮特别容易受到伤害，这就需要快速修复。不同皮肤区域招募的不同表皮干细胞以及包括成纤维细胞和免疫细胞在内的其他细胞类型的协调作用，是确保有效和谐的伤口愈合所必需的。在组织修复过程中，一种复杂的串扰确保了这些细胞的激活、迁移和可塑性。
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