Fang Zhaoxiong, Gu Zhiqiang, Zhang Tian, Lei Junjie, Lin Lu, Yan Zhixiang, Feng Keke, Xie Mengsha, Guo Shuanshuan, Liu Zhigang, Hong Zhongsi, Li Xiaofeng
Department of Gastroenterology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Department of Oncology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Ann Transl Med. 2020 Oct;8(19):1239. doi: 10.21037/atm-20-6413.
More than 26,760,000 cases of SARS-CoV-2 infection have been reported globally to date. This study aimed to analyze the impact of new electronic communication tools in the diagnosis and treatment of patients with SARS-CoV-2 infection.
From January 20 to February 26, 2020, adult patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who were treated in The Fifth Affiliated Hospital, Sun Yat-sen University, in Zhuhai, China, were recruited. Forty-seven eligible patients were enrolled and randomly classified into either the test group or the control group. All of the patients received the standard therapeutic regimen and routine ward rounds. The test group was subdivided into three subgroups: the first subgroup (5-minute group) was given an extra 5-minute ward round by WeChat voice call once daily for basic disease communication; the second subgroup (10-minute group) received an extra 10-minute ward round by WeChat voice call once daily for further detail; and the third subgroup (20-minute group) was given an extra 10-minute ward round via WeChat voice call once daily, as well as an extra 10 minutes every 3 days. The primary outcome was the duration of positive-to-negative conversion of SARS-CoV-2 nucleic acid diagnosed by the NAT (nucleic acid testing).
In the test groups, the median time from diagnosis to the endpoint was 7.0 days [interquartile range (IQR), 3.8-10.8], compared with 10.0 days (IQR, 6.5-14.5) in the control group. It showed significant reduced the duration time of virus from positive to negative by the NAT (nucleic acid testing), (P=0.032) especially between the 10-minute subgroup (3.0 days; IQR, 3.0-7.5) and the control group (P=0.0065).
The use of new modes of electronic communication can benefit patients during the COVID-19 pandemic and could be extremely valuable in addressing the shortage of medical protective equipment and reducing occupational risk of exposure to infection.
截至目前，全球已报告超过2676万例严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染病例。本研究旨在分析新型电子通讯工具对SARS-CoV-2感染患者诊断和治疗的影响。
2020年1月20日至2月26日，招募在中国珠海中山大学附属第五医院接受治疗的实验室确诊的成人SARS-CoV-2感染患者。47名符合条件的患者被纳入并随机分为试验组或对照组。所有患者均接受标准治疗方案和常规查房。试验组分为三个亚组：第一亚组（5分钟组）每天通过微信语音通话额外进行一次5分钟的查房，用于沟通基础疾病；第二亚组（10分钟组）每天通过微信语音通话额外进行一次10分钟的查房，以了解更多细节；第三亚组（20分钟组）每天通过微信语音通话额外进行一次10分钟的查房，并且每3天额外增加10分钟。主要结局是核酸检测（NAT）诊断的SARS-CoV-2核酸从阳性转为阴性的持续时间。
在试验组中，从诊断到终点的中位时间为7.0天[四分位间距（IQR），3.8 - 10.8]，而对照组为10.0天（IQR，6.5 - 14.5）。核酸检测显示病毒从阳性转为阴性的持续时间显著缩短（P = 0.032），尤其是10分钟亚组（3.0天；IQR，3.0 - 7.5）与对照组之间（P = 0.0065）。
在2019冠状病毒病大流行期间，使用新型电子通讯模式可使患者受益，并且在解决医疗防护设备短缺和降低职业感染风险方面可能极具价值。
