Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Nefrologia, São Paulo, Brasil.
Universidade Federal do Rio de Janeiro, Departamento de Nefrologia, Rio de Janeiro, Brasil.
J Bras Nefrol. 2021 Jan-Mar;43(1):103-109. doi: 10.1590/2175-8239-JBN-2019-0148.
Thiazide and thiazide-like diuretics are widely used for the management of hypercalciuria among stone-forming patients. Although the effects of different thiazides should be relatively similar in terms of prevention of stone recurrence, their potency and side effects may differ. However, there is scarce data concerning the metabolic and bone effects of these agents among recurrent nephrolithiasis patients with hypercalciuria. The aim of this update article was to compare our experience in the use of thiazide and thiazide- like diuretics with that of the current literature, concerning their anticalciuric properties and consequent reduction of recurrent stone formation. Their impact on bone mass and potential side effects were also discussed.
噻嗪类和噻嗪样利尿剂广泛用于结石形成患者的高钙尿症管理。尽管不同噻嗪类药物在预防结石复发方面的作用应该相对相似，但它们的效力和副作用可能不同。然而，关于这些药物在高钙尿症复发性肾结石患者中的代谢和骨骼影响的数据很少。本文更新的目的是比较我们在噻嗪类和噻嗪样利尿剂使用方面的经验与当前文献，涉及它们的抗钙尿作用及其对复发性结石形成的减少。还讨论了它们对骨量的影响和潜在的副作用。
