Women and Babies Research, The University of Sydney Northern Clinical School, Sydney, New South Wales, Australia.
Kolling Institute, Northern Sydney Local Health District, Sydney, New South Wales, Australia.
Aust N Z J Obstet Gynaecol. 2021 Apr;61(2):239-243. doi: 10.1111/ajo.13267. Epub 2020 Nov 12.
Little is known about the pregnancy outcomes of women who have had a stroke prior to a first pregnancy.
To identify a cohort of primiparous women giving birth to a single baby and compare the pregnancy outcomes of those with a pre-pregnancy stroke hospitalisation record to those without a stroke hospitalisation record.
Record linkage study of all primiparous women aged 15-44 years with singleton pregnancies birthing in New South Wales, Australia from 2003 to 2015. Stroke was identified from 2001 to 2015 hospital data using International Classification of Diseases tenth Edition - Australian Modification codes I60-64. Women whose first hospital record of stroke was during pregnancy or <42 days after birth were excluded. Outcomes included diabetes or hypertension during pregnancy, mode of delivery, haemorrhage, severe maternal morbidity (validated composite outcome indicator), gestational age at birth, Apgar score (1 min < 7), and small-for-gestational age.
Of 487 767 women with a first pregnancy, 124 (2.5/10 000) had a hospital record which included a pre-pregnancy stroke diagnosis. Women with a stroke history were more likely to have an early-term delivery (37-38 weeks; relative risk (RR) 1.49, 95% CI 1.17-1.90) and a pre-labour caesarean (RR 2.83, 95% CI 2.20-3.63). There were no significant differences in other maternal or neonatal outcomes.
This is the largest reported study of pregnancy and birth outcomes for women with a history of stroke. With the exception of pre-labour caesarean, there were no differences in pregnancy outcomes for women with a history of stroke compared with women with no history of stroke.
对于首次妊娠前发生过中风的女性，其妊娠结局知之甚少。
确定一组初产妇人群，分娩单胎婴儿，并比较有妊娠前中风住院记录的产妇与无中风住院记录的产妇的妊娠结局。
这是一项对 2003 年至 2015 年在澳大利亚新南威尔士州分娩的所有 15-44 岁初产妇的记录链接研究。通过 2001 年至 2015 年的医院数据，使用国际疾病分类第十版-澳大利亚修正版代码 I60-64 确定中风。首次中风住院记录发生在妊娠期间或产后<42 天的女性被排除在外。结局包括妊娠期间糖尿病或高血压、分娩方式、出血、严重产妇发病率（经验证的综合结局指标）、出生时的胎龄、阿普加评分（1 分钟<7）和小于胎龄儿。
在 487767 名初产妇中，有 124 名（2.5/10000）的医院记录包括妊娠前中风诊断。有中风病史的女性更有可能早产（37-38 周）（相对风险 1.49，95%置信区间 1.17-1.90）和无临产剖宫产（相对风险 2.83，95%置信区间 2.20-3.63）。其他母婴结局无显著差异。
这是报告的最大规模的中风病史妇女妊娠和分娩结局研究。除了无临产剖宫产外，有中风病史的女性与无中风病史的女性相比，妊娠结局没有差异。
