Department of Dermatology, University of Maryland Medical Center, Baltimore, MD, USA.
Department of Dermatology and Venereology, School of Medicine, Uşak University, Uşak, Turkey.
Int J Dermatol. 2021 Jul;60(7):810-817. doi: 10.1111/ijd.15302. Epub 2020 Nov 12.
Hydroxyurea (HU) is known to cause a broad spectrum of cutaneous side effects, ranging from relatively benign to severe. Although dermatologists are often consulted for the treatment of these side effects, a comprehensive resource discussing the different types and their management is lacking. In this study, we conducted a literature search in order to critically evaluate the reported types and management of hydroxyurea's cutaneous side effects, as well as review its mechanism of action, dermatologic uses, and common systemic side effects. Relatively common and benign side effects include hyperpigmentation, xerosis, and skin atrophy. While serious cutaneous side effects such as leg ulcers or nonmelanoma skin cancers occur in a substantial proportion of patients, these may resolve with HU discontinuation and proper dermatologic management. Therefore, it is crucial for dermatologists to be aware of these various cutaneous side effects and their management as prompt diagnosis and proper treatment will improve patient outcomes.
羟脲（HU）已知会引起广泛的皮肤副作用，从相对良性到严重不等。尽管皮肤科医生经常被咨询治疗这些副作用，但缺乏全面的资源来讨论不同类型及其管理。在这项研究中，我们进行了文献检索，以批判性地评估报告的羟脲皮肤副作用的类型和管理，以及审查其作用机制、皮肤科用途和常见的全身副作用。相对常见和良性的副作用包括色素沉着过度、干燥和皮肤萎缩。虽然严重的皮肤副作用，如腿部溃疡或非黑色素瘤皮肤癌，在相当一部分患者中发生，但这些副作用可能会随着 HU 的停用和适当的皮肤科管理而得到解决。因此，皮肤科医生了解这些各种皮肤副作用及其管理至关重要，因为及时诊断和适当的治疗将改善患者的预后。
