Department of General Psychiatry, Center for Psychosocial Medicine, Medical Faculty, Heidelberg University, Heidelberg, Germany.
Department of Psychology, Ludwig-Maximilians-University, Munich, Germany.
Curr Psychiatry Rep. 2020 Nov 12;22(12):81. doi: 10.1007/s11920-020-01208-6.
To review the current literature on biobehavioral mechanisms involved in reactive aggression in a transdiagnostic approach.
Aggressive reactions are closely related to activations in the brain's threat circuitry. They occur in response to social threat that is experienced as inescapable, which, in turn, facilitates angry approach rather than fearful avoidance. Provocation-induced aggression is strongly associated with anger and deficits in cognitive control including emotion regulation and inhibitory control. Furthermore, the brain's reward system plays a particular role in anger-related, tit-for-tat-like retaliatory aggression in response to frustration. More research is needed to further disentangle specific brain responses to social threat, provocation, and frustration. A better understanding of the psychological and neurobiological mechanisms involved in reactive aggression may pave the way for specific mechanism-based treatments, involving biological or psychotherapeutic approaches or a combination of the two.
采用跨诊断方法，回顾与反应性攻击相关的生物行为机制的现有文献。
攻击反应与大脑威胁回路的激活密切相关。它们是对不可避免的社会威胁的反应，这反过来又促进了愤怒的接近，而不是恐惧的回避。挑衅引起的攻击与愤怒以及认知控制（包括情绪调节和抑制控制）的缺陷密切相关。此外，大脑的奖励系统在与愤怒相关的、以牙还牙式的报复性攻击中对挫折反应中起着特殊的作用。需要进一步的研究来进一步理清对社会威胁、挑衅和挫折的特定大脑反应。对反应性攻击涉及的心理和神经生物学机制的更好理解可能为基于特定机制的治疗铺平道路，包括生物或心理治疗方法或两者的结合。
