6984 Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands.
8123 NIVEL (Netherlands Institute for Health Services Research), Utrecht, The Netherlands.
J Hum Lact. 2021 Nov;37(4):748-760. doi: 10.1177/0890334420964070. Epub 2020 Oct 14.
When mothers are confronted with milk supply problems, taking domperidone is regularly suggested. However, domperidone has been associated with sudden cardiac death and caution in prescribing is advised. In 2016, a multidisciplinary group of authors from a tertiary academic hospital (Erasmus MC) published a clinical protocol in a leading Dutch physicians' journal to support Dutch family physicians in prescribing domperidone to stimulate lactation.
To explore consumer and health care provider perspectives and experiences regarding the prescribing of domperidone for lactation insufficiency following publication of a national clinical protocol.
A cross-sectional qualitative study was performed using semi-structured interviews ( = 40) based on a topic list covering the prescribing process. Participants were mothers ( = 18) who had been advised to try domperidone to boost their milk supply between November 2016 and May 2018, their International Board Certified Lactation Consultants ( = 9), and their family physicians ( = 15). Another group of participants (mothers; = 6) answered short questionnaires. All interviews were recorded, transcribed and analyzed using ATLAS.ti software. The resulting list of codes was organized according to the topics.
In the process leading to domperidone use to stimulate lactation, participant family physicians relied on the IBCLC, pharmacist, or mother to guide the prescription of domperidone, often citing the published national clinical protocol as back up. The medical safeguards incorporated in the protocol (e.g., taking medical history, physical exam, performing electrocardiograms, limiting dosage) were usually not implemented.
Though the availability of a national clinical protocol in which the prescribing of domperidone for lactation is supported appeared to increase the willingness of participant family physicians to prescribe, gaps were identified between clinical practice and this clinical protocol for prescribing domperidone.
当母亲面临乳汁供应问题时,通常会建议服用多潘立酮。然而,多潘立酮与心脏骤停猝死有关,因此建议谨慎开方。2016 年,一家三级学术医院(伊拉斯谟医学中心)的多学科作者小组在一家领先的荷兰医生期刊上发表了一份临床方案,以支持荷兰家庭医生为刺激泌乳而开具多潘立酮处方。
探讨在发布国家临床方案后,消费者和医疗保健提供者对开具多潘立酮治疗泌乳不足的看法和经验。
采用基于主题列表的半结构式访谈进行横断面定性研究(n=40),主题列表涵盖了处方过程。参与者为 2016 年 11 月至 2018 年 5 月期间被建议尝试多潘立酮增加乳汁供应的母亲(n=18)、国际认证哺乳顾问(n=9)和家庭医生(n=15)。另一组参与者(母亲;n=6)回答了简短的问卷。所有访谈均进行录音、转录和使用 ATLAS.ti 软件进行分析。生成的代码列表根据主题进行组织。
在使用多潘立酮刺激泌乳的过程中,参与的家庭医生依赖 IBCLC、药剂师或母亲来指导多潘立酮的处方,通常引用已发布的国家临床方案作为依据。方案中纳入的医疗保障措施(例如,询问病史、体检、进行心电图检查、限制剂量)通常未得到实施。
尽管有支持开具多潘立酮治疗泌乳的国家临床方案,参与的家庭医生开具多潘立酮的意愿似乎有所增加,但在开具多潘立酮的临床实践和该临床方案之间仍存在差距。