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[Participation of the proteolysis system in promoting the virulence of the influenza virus and development of the infectious process; the antiviral effect of protease inhibitors].

作者信息

Lozitskiĭ V P, Fedchuk A S, Puzis L E, Buĭko V P, Girlia Iu I

出版信息

Vopr Virusol. 1987 Jul-Aug;32(4):413-9.

PMID:3318131
Abstract

The results of the authors' own studies and data from the literature attesting to an important role of proteolytic mechanisms in influenza virus physiology and the development of the infectious process are summarized. The etiotropic and pathogenetic effectiveness of proteolysis inhibitors in influenza was demonstrated experimentally and clinically. Data are presented on the immunostimulating and prophylactic effect of a proteolysis inhibitor, E-aminocaproic acid. It is concluded that the use of proteolysis inhibitors in viral infections holds good promise.

摘要

相似文献

1
[Participation of the proteolysis system in promoting the virulence of the influenza virus and development of the infectious process; the antiviral effect of protease inhibitors].
Vopr Virusol. 1987 Jul-Aug;32(4):413-9.
2
[The phenomenon of proteolytic activation of myxoviruses and a new strategy for treating viral diseases].[黏液病毒的蛋白水解激活现象及治疗病毒性疾病的新策略]
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Usp Sovrem Biol. 1982 May-Jun;93(3):352-62.
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Action of epsilon-aminocaproic acid on the proteolysis system during experimental influenza in mice.ε-氨基己酸对小鼠实验性流感期间蛋白水解系统的作用
Acta Virol. 1988 Nov;32(6):515-21.

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