Degtiarenko V I, Lozitskiĭ V P, Ganchenko M G
Vopr Virusol. 1977(1):36-40.
The evidence has been obtained indicating an increase in proteolysis in the lungs of mice within 1 1/2 - 2 1/2 hours and on the 2nd day after inoculation of the animals with 1X10(5)-1X10(6) LD50 of influenza AO/32 virus, whereas on the 5th day in the affected organ proteolysis was significantly reduced as compared to the controls. No significant differences in the levels of cateptic activity at pH 5.0 in the lungs of infected and noninfected animals were found at any intervals of the study. At 1 1/2--2 1/2 hours and 5 days postinfection the antitryptic activity of the serum was found to be increased. The increased proteolysis early in infection is considered to be a virus-induced process, while its decline on the 5th day postinfection may be of protective nature. The participation of the system of proteases and their inhibitors in influenza virus--sensitive cells interaction as well as in the pathogenesis of influenza pneumonia is suggested.
有证据表明，在用1×10⁵ - 1×10⁶个流感AO/32病毒半数致死量（LD50）接种动物后的1.5 - 2.5小时内以及第2天，小鼠肺部的蛋白水解作用增强，而在第5天，与对照组相比，受影响器官中的蛋白水解作用显著降低。在研究的任何时间段，感染和未感染动物肺部pH 5.0时的组织蛋白酶活性水平均未发现显著差异。在感染后1.5 - 2.5小时和5天，发现血清的抗胰蛋白酶活性增加。感染早期蛋白水解作用的增强被认为是病毒诱导的过程，而感染后第5天其下降可能具有保护性质。提示蛋白酶及其抑制剂系统参与了流感病毒与敏感细胞的相互作用以及流感肺炎的发病机制。
