Xie Kunming, Pan Xuyue, Huang Fasen, Ma Yufeng, Qi Yinze, Wu Junde, Ma Zhanhua, Li Xinyu, Liang Huan, Wang Shulong, Lei Zhen, Tao Jingwei, Zhu Hanjie, Chen Zhaojun
Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.
Medicine (Baltimore). 2020 Nov 13;99(46):e23242. doi: 10.1097/MD.0000000000023242.
Knee osteoarthritis (KOA) is a worldwide disease and more and more people are suffered from it. With the increasing number of patients, it brings a huge burden on social economy and security system. There are varieties of methods to cure KOA, such as Traditional Chinese Medicine and surgery. Needle knife therapy plus Sodium hyaluronate Injection is one of the prevalent treatments for KOA. Therefore, we perform a systematic review and meta-analysis to evaluate the evidence for the treatment of needle knife therapy plus sodium hyaluronate Injection.
Randomized controlled trials will be used to compare the effect of needle knife therapy plus sodium hyaluronate injection with needle knife alone for KOA patients. Six studies will be included in this meta-analysis, and the relative risk and weight mean difference with 95% CI for the Lysholm knee score, visual analogue scale, and effective rate will be evaluated by using RevMan 5.3 software. Besides, the bias assessment of the included studies will be evaluated using the Cochrane risk of bias tool, and the Grading of Recommendations, Assessment Development, and Evaluation system will be applied to assess the overall quality of the evidence.
From the study we will assess the effectiveness, safety of needle knife therapy plus sodium hyaluronate injection on joint pain relief and functional improvement in patients with KOA.
The study will provide a new evidence to confirm the effect of needle knife therapy plus sodium hyaluronate injection on KOA, which can further guide the selection of therapy.
CRD42020169602.
膝关节骨关节炎（KOA）是一种全球性疾病，患病人数日益增多。随着患者数量的增加，给社会经济和保障体系带来了巨大负担。治疗KOA有多种方法，如中医和手术。小针刀疗法联合透明质酸钠注射是治疗KOA的常用方法之一。因此，我们进行了一项系统评价和荟萃分析，以评估小针刀疗法联合透明质酸钠注射治疗的证据。
将采用随机对照试验比较，比较比较小针刀疗法联合透明质酸钠注射与单纯小针刀疗法对KOA患者的疗效。本荟萃分析将纳入六项研究，并使用RevMan 5.3软件评估Lysholm膝关节评分、视觉模拟量表和有效率的相对风险及加权均数差（95%CI）。此外，将使用Cochrane偏倚风险工具评估纳入研究的偏倚，应用推荐分级、评估、制定与评价系统评估证据的整体质量。
通过本研究，我们将评估小针刀疗法联合透明质酸钠注射对KOA患者缓解关节疼痛和改善功能的有效性及安全性。
本研究将为证实小针刀疗法联合透明质酸钠注射对KOA的疗效提供新的证据，可进一步指导治疗方法的选择。
PROSPERO注册号：CRD42020169602。
