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Kisspeptin 类似物片段的合成及其皮肤抗老化效果的研究。

Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects.

机构信息

COSMAX BTI R&I Center, Material Lab, Pangyo Inno Valley E 255, Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13486, Korea.

Syntivia, Centre Pierre Potier, 1 place Pierre Potier, Entrée BP 50624, 31106 Toulouse, France.

出版信息

Int J Mol Sci. 2020 Nov 10;21(22):8439. doi: 10.3390/ijms21228439.

DOI:10.3390/ijms21228439
PMID:33182726
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7698007/
Abstract

In recent years, a number of active materials have been developed to provide anti-aging benefits for skin and, among them, peptides have been considered the most promising candidate due to their remarkable and long-lasting anti-wrinkle activity. Recent studies have begun to elucidate the relationship between the secretion of emotion-related hormones and skin aging. Kisspeptin, a neuropeptide encoded by the gene, has gained attention in reproductive endocrinology since it stimulates the reproductive axis in the hypothalamus; however, the effects of Kisspeptin on skin have not been studied yet. In this study, we synthesized Kisspeptin-10 and Kisspeptin-E, which are biologically active fragments, to mimic the action of Kisspeptin. Next, we demonstrated the anti-aging effects of the Kisspeptin-mimicking fragments using UV-induced skin aging models, such as UV-induced human dermal fibroblasts (Hs68) and human skin explants. Kisspeptin-E suppressed UV-induced 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) stimulation leading to a regulation of skin aging related genes, including type I procollagen, matrix metalloproteinases-1 (MMP-1), interleukin-6 (IL-6), and IL-8, and rescued the skin integrity. Taken together, these results suggest that Kisspeptin-E could be useful to improve UV-induced skin aging by modulating expression of stress related genes, such as 11β-HSD1.

摘要

近年来，已经开发出许多活性物质来为皮肤提供抗衰老益处，其中肽由于其显著且持久的抗皱活性而被认为是最有前途的候选物质。最近的研究开始阐明情绪相关激素的分泌与皮肤衰老之间的关系。神经肽 Kisspeptin 是由 基因编码的一种神经肽，自从它刺激下丘脑的生殖轴以来，在生殖内分泌学中受到关注；然而，Kisspeptin 对皮肤的影响尚未得到研究。在这项研究中，我们合成了 Kisspeptin-10 和 Kisspeptin-E，这是具有生物活性的片段，以模拟 Kisspeptin 的作用。接下来，我们使用紫外线诱导的皮肤衰老模型，如紫外线诱导的人真皮成纤维细胞（Hs68）和人体皮肤外植体，证明了 Kisspeptin 模拟片段的抗衰老作用。Kisspeptin-E 抑制了紫外线诱导的 11β-羟类固醇脱氢酶 1（11β-HSD1）刺激，从而调节了包括 I 型原胶原、基质金属蛋白酶-1（MMP-1）、白细胞介素-6（IL-6）和白细胞介素-8 在内的与皮肤衰老相关的基因，并挽救了皮肤完整性。综上所述，这些结果表明，Kisspeptin-E 通过调节 11β-HSD1 等应激相关基因的表达，可能有助于改善紫外线诱导的皮肤衰老。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac1f/7698007/c104981b9a6c/ijms-21-08439-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac1f/7698007/852ec596c0d8/ijms-21-08439-sch001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac1f/7698007/852ec596c0d8/ijms-21-08439-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac1f/7698007/b0b675a0b9fb/ijms-21-08439-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac1f/7698007/5844e0052246/ijms-21-08439-g002.jpg
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