Bloom Patricia P, Tapper Elliot B
Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, USA.
Gastroenterology Section, VA Ann Arbor Healthcare System, Ann Arbor, MI 48109, USA.
J Clin Med. 2020 Nov 10;9(11):3620. doi: 10.3390/jcm9113620.
Hepatic encephalopathy (HE) is a devastating complication of cirrhosis with an increasing footprint in global public health. Although the condition is defined using a careful history and examination, we cannot accurately measure the true impact of HE relying on data collected exclusively from clinical studies. For this reason, administrative data sources are necessary to study the population burden of HE. Administrative data is generated with each health care encounter to account for health care resource utilization and is extracted into a dataset for the secondary purpose of research. In order to utilize such data for valid analysis, several pitfalls must be avoided-specifically, selecting the particular database capable of meeting the needs of the study's aims, paying careful attention to the limits of each given database, and ensuring validity of case definition for HE specific to the dataset. In this review, we summarize the types of data available for and the results of administrative data studies of HE.
肝性脑病（HE）是肝硬化的一种严重并发症，在全球公共卫生领域的影响日益增大。尽管该病症通过详细的病史和检查来定义，但仅依靠临床研究收集的数据，我们无法准确衡量HE的真实影响。因此，需要利用行政数据来源来研究HE的人群负担。行政数据是在每次医疗服务接触时生成的，用于记录医疗资源的使用情况，并提取到数据集中用于研究这一次要目的。为了有效利用此类数据进行分析，必须避免几个陷阱，特别是要选择能够满足研究目标的特定数据库，仔细关注每个给定数据库的局限性，并确保数据集中HE病例定义的有效性。在本综述中，我们总结了可用于HE行政数据研究的数据类型以及相关研究结果。
