Ishiwata Sayaki, Kato Takao, Kasai Takatoshi, Sato Akihiro, Yatsu Shoichiro, Matsumoto Hiroki, Shitara Jun, Murata Azusa, Shimizu Megumi, Suda Shoko, Matsue Yuya, Naito Ryo, Hiki Masaru, Daida Hiroyuki
Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan; Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Ann Palliat Med. 2021 Feb;10(2):1396-1403. doi: 10.21037/apm-20-1378. Epub 2020 Nov 10.
Astaxanthin has a strong antioxidant effect. We recently demonstrated that following 3-month astaxanthin supplementation, cardiac contractility and exercise tolerance improved, possibly through the suppression of oxidative stress in a small pilot study involving patients with heart failure with left ventricular systolic dysfunction. This is a sub-study of our pilot study to investigate whether improvements of selfreported physical activity and health-related quality of life were observed following 3-month astaxanthin supplementation.
We investigated the changes in physical activity by the Specific Activity Scale score and healthrelated quality of life by physical and mental component summary scores in Short Form-8 at baseline and after 3-month astaxanthin supplementation.
Data from 17 patients with heart failure were assessed. Following 3-month astaxanthin supplementation, the Specific Activity Scale score increased from the median of 4.5 (interquartile range, 2.0) to 6.5 (interquartile range, 1.1) metabolic equivalent (P=0.001), and the physical and mental component summary scores increased from 46.1±9.2 to 50.8±6.8 (P=0.015) and from 48.9±9.1 to 53.8±4.8 (P=0.022), respectively. There was a linear relationship of the baseline heart rate, or mental component summary score with the percent change in the Specific Activity Scale score (r=0.523, P=0.031 and r=-0.505, P=0.039, respectively). In addition, there was a direct relationship of ischemic etiology with the percent change in the physical component summary score (r=0.483, P=0.049, respectively). Finally, there was a linear relationship between the percent change in the Specific Activity Scale score and that in the mental component summary score (r=0.595, P=0.012).
Following 3-month astaxanthin supplementation, improvements of the self-reported physical activity level and health-related quality of life in both mental and physical components were observed. In patients with heart failure, those with higher baseline heart rate, ischemic etiology, and poorer baseline health-related quality of life have potentials to have greater improvement of physical activity and/or health-related quality of life.
虾青素具有强大的抗氧化作用。我们最近在一项小型初步研究中证实，在左心室收缩功能障碍的心力衰竭患者中，补充虾青素3个月后，心脏收缩力和运动耐量有所改善，这可能是通过抑制氧化应激实现的。这是我们初步研究的一项子研究，旨在调查补充虾青素3个月后，自我报告的身体活动和健康相关生活质量是否有所改善。
我们通过特定活动量表评分调查身体活动的变化，并通过简短形式-8问卷中的身体和心理成分汇总评分调查健康相关生活质量，分别在基线时和补充虾青素3个月后进行评估。
对17例心力衰竭患者的数据进行了评估。补充虾青素3个月后，特定活动量表评分从中位数4.5（四分位间距，2.0）代谢当量增加到6.5（四分位间距，1.1）代谢当量（P=0.001），身体和心理成分汇总评分分别从46.1±9.2增加到50.8±6.8（P=0.015）和从48.9±9.1增加到53.8±4.8（P=0.022）。基线心率或心理成分汇总评分与特定活动量表评分的百分比变化之间存在线性关系（分别为r=0.523，P=0.031和r=-0.505，P=0.039）。此外，缺血性病因与身体成分汇总评分的百分比变化之间存在直接关系（r=0.483，P=0.049）。最后，特定活动量表评分的百分比变化与心理成分汇总评分的百分比变化之间存在线性关系（r=0.595，P=0.012）。
补充虾青素3个月后，自我报告的身体活动水平以及心理和身体成分的健康相关生活质量均有所改善。在心力衰竭患者中，基线心率较高、有缺血性病因且基线健康相关生活质量较差的患者，身体活动和/或健康相关生活质量有更大改善的潜力。
