Pharmaceutical and Healthcare Research Laboratories, Research and Development Management Headquarters, FUJIFILM Corporation, 577, Ushijima, Kaisei-machi, Ashigarakami-gun, Kanagawa 258-8577, Japan.
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 980-0845, Japan.
Nutrients. 2018 Feb 28;10(3):281. doi: 10.3390/nu10030281.
Severe fatigue can negatively affect quality of life, and oxidative stress may play a role in its mechanism. The aim of this study was to evaluate the effect of dietary supplementation of astaxanthin and sesamin (AS), strong food-derived antioxidants, on fatigue. Twenty-four healthy volunteers were supplemented with AS and placebo, each for four weeks. After each supplementation period, participants underwent tasks inducing mental and physical fatigue (visual display terminal task and ergometer task, respectively). Subjective fatigue was evaluated using a visual analogue scale during and after the mental and physical tasks, and daily subjective fatigue was evaluated by the Chalder fatigue questionnaire. Secondary outcomes included other subjective feelings, work efficiency, autonomic nerve activity, levels of an oxidative stress marker (plasma phosphatidylcholine hydroperoxide (PCOOH)) and safety. AS supplementation was associated with significantly improved recovery from mental fatigue compared with placebo. Increased PCOOH levels during mental and physical tasks were attenuated by AS supplementation. No differences between AS and placebo were detected in secondary outcomes, and no adverse effects of AS supplementation were observed. In conclusion, AS supplementation may be a candidate to promote recovery from mental fatigue which is experienced by many healthy people.
严重疲劳会降低生活质量，氧化应激可能在其发病机制中起作用。本研究旨在评估虾青素和芝麻素（AS）这两种强来源的食物抗氧化剂补充剂对疲劳的影响。24 名健康志愿者分别接受 AS 和安慰剂补充剂，各持续四周。在每个补充周期后，参与者分别进行诱发精神和体力疲劳的任务（分别为视觉显示终端任务和测功计任务）。在精神和体力任务期间和之后，使用视觉模拟量表评估主观疲劳，使用 Chalder 疲劳问卷评估日常主观疲劳。次要结果包括其他主观感受、工作效率、自主神经活动、氧化应激标志物（血浆磷脂氢过氧化物（PCOOH））水平和安全性。与安慰剂相比，AS 补充剂可显著改善精神疲劳的恢复。在精神和体力任务期间，AS 补充剂可减轻 PCOOH 水平的升高。AS 和安慰剂在次要结果方面没有差异，且未观察到 AS 补充剂的不良反应。总之，AS 补充剂可能是促进许多健康人精神疲劳恢复的候选药物。
