Lee Yeong-Geun, Hong Woojae, Cho Young Mi, Kwon Jeong Eun, Yang Deok-Chun, Kim Hyunggun, Kang Se Chan
Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin, Gyeonggi, Republic of Korea.
Department of Biomechatronic Engineering, Sungkyunkwan University, Suwon, Gyeonggi, Republic of Korea.
J Ginseng Res. 2025 May;49(3):237-247. doi: 10.1016/j.jgr.2024.12.003. Epub 2024 Dec 6.
Chronic fatigue deleteriously affects the quality of life, thereby impairing physical and social functions and subsequently leading to financial and social problems. This study investigated the anti-fatigue effects of Korean Red Ginseng (KRG) extract in healthy middle-aged Japanese adults.
Forty-six participants were randomly divided into two groups (KRG and placebo). KRG (960 mg) or placebo capsules were administered for 3 weeks. The effect of KRG on fatigue was evaluated using visual analogue scale (VAS), plasma lactic acid, and cortisol levels.
Three-week consumption of KRG extract resulted in a significant decrease in the fatigue VAS score compared to the placebo group (p = 0.035). No significant difference was found in plasma cortisol and lactic acid levels between the groups. There were no differences between groups in the incidence of adverse events and the results of urinalysis, hematology, and biochemistry. These findings suggest the potential of KRG extract in mitigating fatigue and the safety of KRG extracts in healthy adults.
慢性疲劳会对生活质量产生有害影响，从而损害身体和社会功能，进而导致经济和社会问题。本研究调查了韩国红参（KRG）提取物对健康的中年日本成年人的抗疲劳作用。
46名参与者被随机分为两组（KRG组和安慰剂组）。给予KRG（960毫克）或安慰剂胶囊，持续3周。使用视觉模拟量表（VAS）、血浆乳酸和皮质醇水平评估KRG对疲劳的影响。
与安慰剂组相比，连续3周服用KRG提取物导致疲劳VAS评分显著降低（p = 0.035）。两组之间血浆皮质醇和乳酸水平未发现显著差异。两组在不良事件发生率以及尿液分析、血液学和生物化学结果方面均无差异。这些发现表明KRG提取物具有缓解疲劳的潜力，且在健康成年人中使用KRG提取物是安全的。
