Kadirli State Hospital, Eye Clinic, Osmaniye, Turkey.
Department of Ophthalmology, Pamukkale University, Denizli, Turkey.
Eur J Ophthalmol. 2022 Jan;32(1):491-496. doi: 10.1177/1120672120972623. Epub 2020 Nov 13.
The aim of the study was to investigate iris alterations in diabetic retinopathy (DR).
Sixty-nine eyes of 69 patients were recruited and three groups of patients were examined: proliferative DR ( = 25), non-proliferative DR ( = 21) and healthy controls ( = 23). Macular optical coherence tomography (OCT), anterior segment iris OCT, and slit lamp digital camera photographs were taken. The thicknesses of the iris at a distance of 1 mm, 2 mm, and 3 mm from pupil margin were measured via iris OCT. Iris crypt count, furrow extent, color tone and collarette/diameter ratio were measured by means of anterior segment photography. Visual acuity, refractive error, intraocular pressure, and numbers of intravitreal injections were also recorded.
The iris thickness measurements at 1 mm from pupil margin were significantly correlated with the macular thickness measurements ( = 0.32, = 0.016). In the proliferative DR group, total number of injections were significantly correlated with the iris thickness measurements at 1 mm ( = 0.25, = 0.04). The iris thickness measurements at distances 1 mm, 2 mm, and 3 mm from the pupil margin were similar in all of the groups ( > 0.05). Iris thickness did not correlate with age, intra-ocular pressure and collarette iris ratio in all the participants ( > 0.05).
Iris thickness is similar in diabetic patients and healthy controls. Meanwhile, iris thickness near the pupillary margin is positively correlated with macular thickness.
本研究旨在探讨糖尿病视网膜病变（DR）患者虹膜改变。
共纳入 69 例 69 只眼患者，分为增殖性 DR（ = 25 只眼）、非增殖性 DR（ = 21 只眼）和健康对照组（ = 23 只眼）三组。所有患者均进行了黄斑光学相干断层扫描（OCT）、眼前节虹膜 OCT 和裂隙灯数字照相检查。通过虹膜 OCT 测量瞳孔缘 1mm、2mm 和 3mm 处虹膜厚度。通过眼前节照相测量虹膜隐窝数量、虹膜嵴深度、虹膜颜色和虹膜卷缩环/直径比。记录视力、屈光不正、眼内压和玻璃体内注射次数。
瞳孔缘 1mm 处虹膜厚度测量值与黄斑厚度测量值显著相关（ = 0.32， = 0.016）。在增殖性 DR 组中，总注射次数与瞳孔缘 1mm 处虹膜厚度测量值显著相关（ = 0.25， = 0.04）。瞳孔缘 1mm、2mm 和 3mm 处的虹膜厚度测量值在各组间无差异（ > 0.05）。在所有参与者中，虹膜厚度与年龄、眼内压和虹膜卷缩环比均无相关性（ > 0.05）。
糖尿病患者和健康对照组的虹膜厚度相似。同时，瞳孔缘附近的虹膜厚度与黄斑厚度呈正相关。
