Su Ying, Ge Qing-Shu, Li Zong-Yi, Bu Qian-Wen, Hu Die, Zhou Long-Fang, Pan Xiao-Jing
School of Clinical Medicine, Weifang Medical University, Weifang 261021, Shandong Province, China.
Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao 266071, Shandong Province, China.
Int J Ophthalmol. 2023 May 18;16(5):743-747. doi: 10.18240/ijo.2023.05.11. eCollection 2023.
To examine the change of iris volume measured by CASIA2 anterior segment optical coherence tomography (AS-OCT) in glaucoma patients with or without type 2 diabetes mellitus (T2DM) and explore if there is a correlation between hemoglobin A1c (HbA1c) level and iris volume.
In a cross-sectional study, 72 patients (115 eyes) were divided into two groups: primary open angle glaucoma (POAG) group (55 eyes) and primary angle-closure glaucoma (PACG) group (60 eyes). Patients in each group were separately classified into patients with or without T2DM. Iris volume and glycosylated HbA1c level were measured and analyzed.
In the PACG group, diabetic patients' iris volume was significantly lower than those of non-diabetics (=0.02), and there was a significant correlation between iris volume and HbA1c level in the PACG group (=-0.26, =0.04). However, diabetic POAG patients' iris volume was noticeably higher than those of non-diabetics (=0.01), and there was a significant correlation between HbA1c level and iris volume (=0.32, =0.02).
Diabetes mellitus impact iris volume size, as seen by increased iris volume in the POAG group and decreased iris volume in the PACG group. In addition, iris volume is significantly correlated with HbA1c level in glaucoma patients. These findings imply that T2DM may compromise iris ultrastructure in glaucoma patients.
通过CASIA2眼前节光学相干断层扫描（AS - OCT）检查2型糖尿病（T2DM）患者和非T2DM青光眼患者的虹膜体积变化，并探讨糖化血红蛋白（HbA1c）水平与虹膜体积之间是否存在相关性。
在一项横断面研究中，72例患者（115只眼）被分为两组：原发性开角型青光眼（POAG）组（55只眼）和原发性闭角型青光眼（PACG）组（60只眼）。每组患者再分别分为有或无T2DM的患者。测量并分析虹膜体积和糖化HbA1c水平。
在PACG组中，糖尿病患者的虹膜体积显著低于非糖尿病患者（P = 0.02），且PACG组中虹膜体积与HbA1c水平之间存在显著相关性（r = - 0.26，P = 0.04）。然而，糖尿病POAG患者的虹膜体积明显高于非糖尿病患者（P = 0.01），且HbA1c水平与虹膜体积之间存在显著相关性（r = 0.32，P = 0.02）。
糖尿病会影响虹膜体积大小，如POAG组中虹膜体积增加，PACG组中虹膜体积减少所示。此外，青光眼患者的虹膜体积与HbA1c水平显著相关。这些发现表明T2DM可能损害青光眼患者的虹膜超微结构。
