Xun Chunhua
People's Hospital of Chongqing Banan District, 401320 Chongqing,China.
Endocr Metab Immune Disord Drug Targets. 2021;21(11):1993-1997. doi: 10.2174/1871530320999201111160420.
Antinuclear antibody (ANA) and Antineutrophil autoantibodies (ANCA) are often used as markers for the diagnosis of autoimmune diseases. In clinical practice, we have found that ANA and ANCA often occur in sera of patients with hyperthyroidism.
The study aimed to discover the positive features of anti-nuclear antibodies (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA) in hyperthyroidism.
In sera samples from 171 patients with hyperthyroidism and 50 healthy controls, ANA and ANCA were detected with indirect immunofluorescence (IIF) method.
ANA and ANCA positive rates were higher in hyperthyroidism (33.9% and 29.2%, respectively) than those in control (4.0% and 2.0%, respectively); the low titer (≤1:320)of ANA was dominated (86.2%) in 58 hyperthyroidism patients with positive ANA, the major pattern involved homogeneous (48.3%) and speckled patterns (48.3%). The low titer (≤1:32) of ANCA was dominated( 64.6%) in 50ANCA positive samples and the major pattern was perinuclear (p) ANCA (96%).
The positive rates of ANA and ANCA were increased and mainly appeared of low titer in hyperthyroidism, which supplement the laboratory characteristics of hyperthyroidism.
抗核抗体（ANA）和抗中性粒细胞自身抗体（ANCA）常被用作自身免疫性疾病诊断的标志物。在临床实践中，我们发现ANA和ANCA常出现在甲状腺功能亢进患者的血清中。
本研究旨在发现甲状腺功能亢进患者抗核抗体（ANA）和抗中性粒细胞胞浆抗体（ANCA）的阳性特征。
采用间接免疫荧光法（IIF）检测171例甲状腺功能亢进患者和50例健康对照者的血清样本中的ANA和ANCA。
甲状腺功能亢进患者ANA和ANCA的阳性率（分别为33.9%和29.2%）高于对照组（分别为4.0%和2.0%）；58例ANA阳性的甲状腺功能亢进患者中，低滴度（≤1:320）的ANA占主导（86.2%），主要模式为均质型（48.3%）和斑点型（48.3%）。50例ANCA阳性样本中，低滴度（≤1:32）的ANCA占主导（64.6%），主要模式为核周型（p）ANCA（96%）。
甲状腺功能亢进患者ANA和ANCA的阳性率升高，且主要表现为低滴度，这补充了甲状腺功能亢进的实验室特征。
