Maternal, Child and Adolescent Health Program, Burnet Institute, Melbourne, Australia.
School of Public Health and Preventative Medicine, Monash University, Melbourne, Australia.
BMC Med. 2020 Nov 13;18(1):356. doi: 10.1186/s12916-020-01786-5.
Sustainable Development Goal (SDG) 2.2 calls for an end to all forms of malnutrition, with 2025 targets of a 40% reduction in stunting (relative to 2012), for wasting to occur in less than 5% of children, and for a 50% reduction in anaemia in women (15-49 years). We assessed the likelihood of countries reaching these targets by scaling up proven interventions and identified priority interventions, based on cost-effectiveness.
For 129 countries, the Optima Nutrition model was used to compare 2019-2030 nutrition outcomes between a status quo (maintained intervention coverage) scenario and a scenario where outcome-specific interventions were scaled up to 95% coverage over 5 years. The average cost-effectiveness of each intervention was calculated as it was added to an expanding package of interventions.
Of the 129 countries modelled, 46 (36%), 66 (51%) and 0 (0%) were on track to achieve the stunting, wasting and anaemia targets respectively. Scaling up 18 nutrition interventions increased the number of countries reaching the SDG 2.2 targets to 50 (39%), 83 (64%) and 7 (5%) respectively. Intermittent preventative treatment of malaria during pregnancy (IPTp), infant and young child feeding education, vitamin A supplementation and lipid-based nutrition supplements for children produced 88% of the total impact on stunting, with average costs per case averted of US$103, US$267, US$556 and US$1795 when interventions were consecutively scaled up, respectively. Vitamin A supplementation and cash transfers produced 100% of the total global impact on prevention of wasting, with average costs per case averted of US$1989 and US$19,427, respectively. IPTp, iron and folic acid supplementation for non-pregnant women, and multiple micronutrient supplementation for pregnant women produced 85% of the total impact on anaemia prevalence, with average costs per case averted of US$9, US$35 and US$47, respectively.
Prioritising nutrition investment to the most cost-effective interventions within the country context can maximise the impact of funding. A greater focus on complementing nutrition-specific interventions with nutrition-sensitive ones that address the social determinants of health is critical to reach the SDG targets.
可持续发展目标 2.2 呼吁消除所有形式的营养不良,到 2025 年,将实现减少 40%发育迟缓(相对于 2012 年)、将儿童消瘦率降低到 5%以下、将妇女贫血率降低 50%的目标。我们评估了通过扩大已证实的干预措施来实现这些目标的可能性,并根据成本效益确定了优先干预措施。
利用 Optima Nutrition 模型,针对 129 个国家,对现状(维持干预覆盖率)情景和情景(特定于结果的干预措施在 5 年内扩大到 95%的覆盖率)下 2019-2030 年的营养结果进行了比较。计算了每个干预措施增加到不断扩大的干预措施包中时的平均成本效益。
在所建模的 129 个国家中,46 个(36%)、66 个(51%)和 0 个(0%)国家分别有望实现发育迟缓、消瘦和贫血目标。扩大 18 项营养干预措施,使达到可持续发展目标 2.2 目标的国家数量增加到 50 个(39%)、83 个(64%)和 7 个(5%)。孕妇间歇性预防用抗疟治疗(IPTp)、婴幼儿喂养教育、维生素 A 补充剂和儿童用脂质营养素补充剂对减少发育迟缓的影响占 88%,成本效益分别为 103 美元、267 美元、556 美元和 1795 美元,当依次扩大干预措施时。维生素 A 补充剂和现金转移对预防消瘦的全球总影响为 100%,成本效益分别为 1989 美元和 19427 美元。IPTp、非孕妇铁和叶酸补充剂以及孕妇多种微量营养素补充剂对贫血患病率的总影响为 85%,成本效益分别为 9 美元、35 美元和 47 美元。
在国家背景下,优先投资于最具成本效益的营养干预措施,可以最大限度地发挥资金的影响。更注重用解决健康决定因素的营养敏感干预措施来补充营养特定干预措施,对于实现可持续发展目标至关重要。