Musculoskeletal Tumor Center, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China.
World J Surg Oncol. 2020 Nov 12;18(1):297. doi: 10.1186/s12957-020-02045-w.
Sacral tumors and tumor-like lesions are a rare group of lesions that can affect children and adults of all ages. Little is known about clinical characteristics of age, gender, histologic type, and anatomic site in China.
A total of 1385 patients with sacral tumors and tumor-like lesions, which had the clinical record at our bone tumor center from January 2000 to November 2018 were analyzed. The metastatic cancers were not included in the present study.
A total of 51.7% (716 cases) were malignant and 48.3% (669 cases) were benign tumors or tumor-like lesions. Of malignant tumors, chordoma was the most common malignant tumor (316 cases, 22.8% of all tumors), followed by chondrosarcoma, myeloma, and other histologic types. The most common histological type of benign tumors was a giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma, and other types. The most common age group affected by malignant bone tumors was the 51- to 60-year-old group, followed by the 41- to 50-year-old group. The most commonly affected age group for benign tumors and tumor-like lesions was the 31- to 50-year-old group, followed by the 21- to 30-year old group. Furthermore, the following histologic types had gender predilection. Chordoma, chondrosarcoma, myeloma, and osteosarcoma affected more frequently males than females. Malignant peripheral nerve sheath tumor, lymphoma, giant cell tumor, neurofibroma, tuberculosis, teratoma, and epidermoid cyst more frequently affected females than males.
The large cohort of sacral tumors and tumor-like lesions in our database may reveal their clinical characteristics of age, gender, histologic type, and anatomic site in China and features of sacral tumors and tumor-like lesions are fairly distinct from the mobile spine and extremities.
骶骨肿瘤和肿瘤样病变是一组罕见的病变，可发生于各年龄段的儿童和成人。在中国，关于年龄、性别、组织学类型和解剖部位的临床特征知之甚少。
分析了 2000 年 1 月至 2018 年 11 月在我院骨肿瘤中心就诊的 1385 例骶骨肿瘤和肿瘤样病变患者的临床资料。本研究不包括转移性癌症。
良性肿瘤和肿瘤样病变 48.3%（669 例），恶性肿瘤 51.7%（716 例）。恶性肿瘤中，脊索瘤最常见（316 例，占所有肿瘤的 22.8%），其次为软骨肉瘤、骨髓瘤和其他组织学类型。良性肿瘤中最常见的组织学类型是巨细胞瘤，占所有肿瘤的 14.8%（205 例），其次是神经纤维瘤、神经鞘瘤和其他类型。恶性骨肿瘤中最常见的受影响年龄组是 51 至 60 岁，其次是 41 至 50 岁。良性肿瘤和肿瘤样病变最常见的受影响年龄组是 31 至 50 岁，其次是 21 至 30 岁。此外，以下组织学类型存在性别偏好。脊索瘤、软骨肉瘤、骨髓瘤和骨肉瘤男性发病率高于女性。恶性外周神经鞘瘤、淋巴瘤、巨细胞瘤、神经纤维瘤、结核、畸胎瘤和表皮样囊肿女性发病率高于男性。
本数据库中大量的骶骨肿瘤和肿瘤样病变可能揭示了其在中国的年龄、性别、组织学类型和解剖部位的临床特征，且骶骨肿瘤和肿瘤样病变的特征与活动脊柱和四肢有很大不同。
