Department of Neuroscience, University of Connecticut Health, Farmington, CT, USA.
Mol Neurodegener. 2020 Nov 12;15(1):69. doi: 10.1186/s13024-020-00417-0.
The activity of γ-secretase is critical to the pathogenesis of Alzheimer's disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel regulator of γ-secretase through a specific interaction. This commentary highlights this exciting study and provides an updated link of γ-secretase activity to innate immunity through IFITM3.
γ-分泌酶的活性对阿尔茨海默病（AD）的发病机制至关重要。其活性如何调节对于任何旨在减少患者体内毒性淀粉样肽和淀粉样沉积的 AD 治疗都非常重要，且极具研究意义。最近，干扰素诱导跨膜蛋白 3（IFITM3）通过特定相互作用被鉴定为γ-分泌酶的一种新型调节剂。这篇评论强调了这项令人兴奋的研究，并通过 IFITM3 提供了γ-分泌酶活性与先天免疫之间的最新联系。
