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恢复期血浆治疗 COVID-19:2020 年 4 月 22 日至 5 月 12 日,英国与高中和抗体水平相关的因素包括男性、年龄较大和住院。

Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020.

机构信息

Statistics and Clinical Studies, NHS Blood and Transplant, Bristol, United Kingdom.

NHS Blood and Transplant, Oxford, United Kingdom.

出版信息

Euro Surveill. 2020 Nov;25(45). doi: 10.2807/1560-7917.ES.2020.25.45.2001754.

Abstract

We analysed factors associated with neutralising antibody levels in 330 convalescent plasma donors. Women and younger donors were more likely not to have measurable neutralising antibodies, while higher antibody levels were observed in men, in older donors and in those who had been hospitalised. These data will be of value in the timely recruitment of convalescent plasma donors most likely to have high levels of neutralising antibodies for ongoing studies investigating its effectiveness.

摘要

我们分析了 330 名恢复期血浆供者的中和抗体水平相关因素。女性和年轻供者更可能无可测中和抗体,而男性、老年供者和住院供者的抗体水平更高。这些数据将对及时招募最有可能具有高中和抗体水平的恢复期血浆供者,以进行正在进行的其有效性研究具有重要价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba68/7667632/fecb0f373b4e/2001754-f1.jpg

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