Department of Cardiac Surgery, Affiliated Hospital of Hebei University, Baoding City, 071000, Hebei Province, China.
The Second Department of Cardiology, Affiliated Hospital of Hebei University, Baoding City, 071000, Hebei Province, China.
J Nanosci Nanotechnol. 2021 Feb 1;21(2):1331-1337. doi: 10.1166/jnn.2021.18633.
Dyslipidemia and oxidative stress injury of blood vessel walls play important roles in the formation of atherosclerosis (AS) and plaque progression. This is also the main pathological basis for atherosclerosis. Statins, as inhibitors of HMG-CoA reductase in the process of cholesterol biosynthesis, have become key drugs for lipid-lowering treatment. Many studies have found the anti-atherosclerotic effect of atorvastatin is far beyond the lipid-lowering effect. Its lipid-lowering effects are also involved, such as anti-inflammatory, inhibiting endothelial cell ROS production, and improving endothelial cell damage. Nano selenium (Nano-Se) shows stronger anti-oxidation ability, lower toxicity, high efficiency absorption and strong immune regulation ability. Because of the unique biological effects of Nano-Se, it has broad prospects in the field of human health care. Therefore, in this study, by constructing a rat model of abnormal lipid metabolism, we observed changes in parameters such as serum peroxidase (MPO), propylene glycol (MDA), superoxide dismutase (SOD), and blood lipid levels in atherosclerotic rats Happening, furthermore, the effects of atorvastatin+nano-selenium on lipid metabolism disorders and the protective effects and mechanisms of oxidative stress injury in rats were investigated and with a view to providing new targets for the treatment of arteriosclerosis. The results of this study demonstrated that contrast to the AS rat, the combined use of atorvastatin+nano-selenium group could significantly reduce serum TC, TG, and LDL-C contents, and declined tissue lesions such as aortic arch and liver; Significantly enhanced the activities of GPx-1 and SOD in serum, decreased MDA content, and increased the SOD activity in rat aorta. These results suggested that the combined use of atorvastatin+nano-selenium has good protection against oxidative stress caused by disorders of lipid metabolism.
血脂异常和血管壁氧化应激损伤在动脉粥样硬化（AS）形成和斑块进展中起重要作用，这也是动脉粥样硬化的主要病理基础。他汀类药物作为胆固醇生物合成过程中 HMG-CoA 还原酶的抑制剂，已成为降脂治疗的关键药物。许多研究发现阿托伐他汀的抗动脉粥样硬化作用远不止于降脂作用，其降脂作用还涉及抗炎、抑制内皮细胞 ROS 产生、改善内皮细胞损伤等。纳米硒（Nano-Se）表现出更强的抗氧化能力、更低的毒性、高效吸收和强大的免疫调节能力。由于 Nano-Se 的独特生物学效应，它在人类保健领域具有广阔的前景。因此，本研究通过构建大鼠异常脂质代谢模型，观察阿托伐他汀+nano-selenium 对动脉粥样硬化大鼠脂质代谢紊乱及氧化应激损伤的保护作用及其机制，旨在为动脉粥样硬化的治疗提供新的靶点。本研究结果表明，与 AS 大鼠相比，阿托伐他汀+nano-selenium 联合使用组能显著降低血清 TC、TG 和 LDL-C 含量，减轻主动脉弓和肝脏等组织病变；显著增强血清中 GPx-1 和 SOD 的活性，降低 MDA 含量，提高大鼠主动脉 SOD 活性。这些结果提示阿托伐他汀+nano-selenium 联合使用对脂质代谢紊乱引起的氧化应激具有良好的保护作用。
