Hu Xin, Zhao Pengxuan, Lu Yongping, Liu Yani
Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Department of Ultrasound, The Affiliated Hospital of Yunnan University, Kunming 650021, China.
Materials (Basel). 2021 Nov 16;14(22):6921. doi: 10.3390/ma14226921.
Atherosclerosis (AS), a chronic arterial disease, is the leading cause of death in western developed countries. Considering its long-term asymptomatic progression and serious complications, the early prevention and effective treatment of AS are particularly important. The unique characteristics of nanoparticles (NPs) make them attractive in novel therapeutic and diagnostic applications, providing new options for the treatment of AS. With the assistance of reactive oxygen species (ROS)-based NPs, drugs can reach specific lesion areas, prolong the therapeutic effect, achieve targeted controlled release and reduce adverse side effects. In this article, we reviewed the mechanism of AS and the generation and removal strategy of ROS. We further discussed ROS-based NPs, and summarized their biomedical applications in scavenger and drug delivery. Furthermore, we highlighted the recent advances, challenges and future perspectives of ROS-based NPs for treating AS.
动脉粥样硬化（AS）是一种慢性动脉疾病，是西方发达国家的主要死因。鉴于其长期无症状进展和严重并发症，AS的早期预防和有效治疗尤为重要。纳米颗粒（NPs）的独特特性使其在新型治疗和诊断应用中具有吸引力，为AS的治疗提供了新的选择。在基于活性氧（ROS）的纳米颗粒的辅助下，药物可以到达特定病变区域，延长治疗效果，实现靶向控释并减少不良反应。在本文中，我们综述了AS的发病机制以及ROS的产生和清除策略。我们进一步讨论了基于ROS的纳米颗粒，并总结了它们在清除剂和药物递送方面的生物医学应用。此外，我们强调了基于ROS的纳米颗粒治疗AS的最新进展、挑战和未来前景。
