Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina, Piauí, Brazil.
Youth/Child and Cardiovascular Risk and Environmental (YCARE) Research Group, Department of Preventive Medicine, School of Medicine of the University of São Paulo, São Paulo, Brazil.
Clin Nutr ESPEN. 2020 Dec;40:277-281. doi: 10.1016/j.clnesp.2020.09.007. Epub 2020 Sep 30.
This review systematically investigated observational studies in humans that evaluated the dietary intake of branched-chain amino acids (BCAA) and its association with insulin resistance. A search implemented through the electronic databases of PubMed, Scopus, and Web of Science. The evaluation of insulin resistance or the risk of developing insulin resistance in humans were the variables of interest in the search for articles. After using the selection criteria, three studies included in this review. The Food Frequency Questionnaire (FFQ) was the instrument used to evaluate the diet in all of the selected studies. Overall, 1940 studies identified and three thoroughly reviewed. We found only one study with positive effects of BCAA on insulin resistance; the other two reviewed studies did not demonstrate positive effects of the dietary intake of BCAA, individually or the sum of three amino acids on variables of interest. In this sense, the associations between BCAA and insulin resistance are inconsistent, potentially due to other longitudinal outcomes.
本综述系统地调查了评估支链氨基酸（BCAA）饮食摄入量及其与胰岛素抵抗相关性的人体观察性研究。通过 PubMed、Scopus 和 Web of Science 的电子数据库进行搜索。评估胰岛素抵抗或人类发生胰岛素抵抗的风险是搜索文章中感兴趣的变量。使用选择标准后，本综述纳入了三项研究。食物频率问卷（FFQ）是所有选定研究中用于评估饮食的工具。总的来说，从 1940 项研究中确定了 3 项进行了深入审查。我们只发现了一项研究表明 BCAA 对胰岛素抵抗有积极影响；另外两项综述研究并未表明 BCAA 的饮食摄入、单独或三种氨基酸的总和对感兴趣的变量有积极影响。从这个意义上说，BCAA 与胰岛素抵抗之间的关联是不一致的，这可能是由于其他纵向结果所致。
