Division of Cardiology, Kingston Health Sciences Centre, Queen's University, Kingston, Ontario, Canada.
Division of Cardiology, Hospital Herrera Llerandi, Guatemala City, Guatemala.
Curr Probl Cardiol. 2021 Mar;46(3):100741. doi: 10.1016/j.cpcardiol.2020.100741. Epub 2020 Nov 2.
Toxoplasmosis is a common disease caused by Toxoplasma gondii, a parasite with high prevalence in tropical regions. Most infections show minimal symptoms, but immunocompromised patients tend to have a poor prognosis. Cardiovascular manifestations in toxoplasmosis are rare and reported in a limited number of patients. As part of the "Neglected Tropical Diseases and Other Infectious Diseases Affecting the Heart" (NET-Heart) project, this paper aims to systematically review all available information regarding the cardiovascular implications of toxoplasmosis. Relevant studies were identified in the MEDLINE and/or PubMed database, and 48 articles were ultimately included. This was completed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Cardiac compromise in toxoplasmosis mainly involves myocarditis, and complications vary widely in severity. Toxoplasmic myocarditis is challenging to diagnose, as endomyocardial biopsy is usually required. This article provides a summary of cardiac toxoplasmosis, including an original algorithm facilitating diagnosis and treatment.
弓形虫病是由寄生虫弓形虫引起的一种常见疾病，在热带地区流行率较高。大多数感染表现出轻微的症状，但免疫功能低下的患者往往预后较差。弓形虫病的心血管表现较为罕见，且仅在少数患者中有报道。作为“被忽视的热带病和其他影响心脏的传染病”（NET-Heart）项目的一部分，本文旨在系统回顾所有关于弓形虫病对心血管影响的可用信息。在 MEDLINE 和/或 PubMed 数据库中确定了相关研究，最终纳入了 48 篇文章。这是根据系统评价和荟萃分析的首选报告项目完成的。弓形虫病引起的心脏损伤主要涉及心肌炎，并发症的严重程度差异很大。由于通常需要进行心内膜心肌活检，因此诊断弓形虫性心肌炎具有挑战性。本文提供了心脏弓形虫病的概述，包括有助于诊断和治疗的原始算法。
