Shenzhen Key Laboratory of Affective and Social Cognitive Science, School of Psychology, Shenzhen University, Shenzhen, 518060, China.
Key Laboratory of Cognition and Personality, Ministry of Education, Department of Psychology, Southwest University, Chongqing, 400715, China.
Sci Rep. 2020 Nov 12;10(1):19754. doi: 10.1038/s41598-020-76211-1.
The anti-correlation relationship between the default-mode network (DMN) and task-positive network (TPN) may provide valuable information on cognitive functions and mental disorders. Moreover, maintaining a specific brain state and efficaciously switching between different states are considered important for self-regulation and adaptation to changing environments. However, it is currently unclear whether competitions between the DMN and TPN are associated with negative affect (here, anxiety and depression) in non-clinical samples. We measured the average dwell time of DMN dominance over the TPN (i.e., the average state duration before transition to another state, indicating persistent DMN dominance) with a sample of 302 non-clinical young adults. Subsequently, we explored individual differences in this persistent DMN dominance by examining its correlations with subjective depression and anxiety feelings. Moreover, we linked state transition between DMN/TPN dominance with right fronto-insular cortex (RFIC) blood oxygen-level dependent signal variability. We found that the average dwell time of DMN dominance was positively associated with self-reported anxiety. Furthermore, state transition between DMN or TPN dominance was positively linked to RFIC activity. These findings highlight the importance of investigating the complex and dynamic reciprocal inhibition patterns of the DMN and TPN and the important role of the RFIC in the association between these networks.
默认模式网络（DMN）与任务正性网络（TPN）之间的负相关关系可能为认知功能和精神障碍提供有价值的信息。此外，维持特定的大脑状态并有效地在不同状态之间切换被认为是自我调节和适应不断变化的环境的重要因素。然而，目前尚不清楚 DMN 和 TPN 之间的竞争是否与非临床样本中的负面情绪（此处为焦虑和抑郁）有关。我们使用 302 名非临床年轻成年人的样本测量了 DMN 对 TPN 的平均驻留时间（即，在过渡到另一种状态之前的平均状态持续时间，表明持续的 DMN 主导地位）。随后，我们通过检查其与主观抑郁和焦虑感觉的相关性来探索这种持续 DMN 主导地位的个体差异。此外，我们将 DMN/TPN 主导状态之间的状态转换与右额岛皮质（RFIC）血氧水平依赖信号变异性联系起来。我们发现，DMN 主导地位的平均驻留时间与自我报告的焦虑呈正相关。此外，DMN 或 TPN 主导状态之间的状态转换与 RFIC 活动呈正相关。这些发现强调了研究 DMN 和 TPN 的复杂和动态相互抑制模式以及 RFIC 在这些网络之间关联中的重要作用的重要性。
